Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 2/20 | 0.58 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.58 |
| ▸ | ITGAL | P20701 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 7/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.55 |
| ▸ | MC4R | P32245 | 1/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224568 | 0.95 | ITGB2 (0.55) | ITGB2ICAM1ITGALKDM4ERAB9A | |
| SCHEMBL1198783 | 0.89 | ITGB2 (0.71) | ITGB2ICAM1ITGALKDM4ERAB9A | |
| SCHEMBL4823256 | 0.89 | KDM4E (0.65) | ITGB2ICAM1ITGALKDM4ERAB9A | |
| SCHEMBL4829071 | 0.88 | KDM4E (0.72) | KDM4ERAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL12875465 | 0.81 | RAB9A (0.63) | ITGB2ICAM1ITGALKDM4ERAB9A | |
| SCHEMBL14224469 | 0.81 | ITGB2 (0.47) | ITGB2ICAM1ITGALKDM4ERAB9A | |
| SCHEMBL12875471 | 0.81 | RAB9A (0.72) | ITGB2ICAM1ITGALKDM4ERAB9A | |
| SCHEMBL6255206 | 0.80 | RAB9A (0.58) | ITGB2ICAM1ITGALKDM4ERAB9A | |
| SCHEMBL14196468 | 0.79 | RAB9A (0.60) | ITGB2ICAM1ITGALKDM4ERAB9A | |
| SCHEMBL12875487 | 0.79 | KDM4E (0.76) | ITGB2ICAM1ITGALKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358267-B2 | Bis-aryl thiazole derivatives | AMGEN INC. (US) | 2008-04-15 | — | — | US | disclosed |
| US-7358267-B2 | Bis-aryl thiazole derivatives | AMGEN INC. (US) | 2008-04-15 | — | — | US | disclosed |
| US-20050215608-A1 | Bis-aryl thiazole derivatives | AMGEN INC. | 2005-09-29 | — | — | US | disclosed |
| WO-2003002062-A2 | BIS-ARYL THIAZOLE DERIVATIVES | TULARIK INC. (US) | 2003-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215608-A1 | Bis-aryl thiazole derivatives | FABP4, PC, TXNRD2 | ITGB2 4717/4885ICAM1 4018/4885ITGAL 4825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.