Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 2/20 | 0.47 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.47 |
| ▸ | ITGAL | P20701 | 2/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 8/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224259 | 0.89 | ITGB2 (0.60) | ITGB2ICAM1ITGALITGB3ITGA2B | |
| SCHEMBL14224468 | 0.89 | KDM4E (0.47) | ITGB2ICAM1ITGALITGB3ITGA2B | |
| SCHEMBL14224472 | 0.87 | RAB9A (0.47) | ITGB3ITGA2BKDM4EMEN1KMT2A | |
| SCHEMBL4829469 | 0.81 | ITGB2 (0.58) | ITGB2ICAM1ITGALITGB3ITGA2B | |
| SCHEMBL14224256 | 0.80 | MAPT (0.52) | KDM4EMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL14224476 | 0.78 | KDM4E (0.46) | ITGB2ICAM1ITGALKDM4EMEN1 | |
| SCHEMBL14224258 | 0.78 | MAPT (0.50) | KDM4EMEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL14224257 | 0.78 | MAPT (0.54) | ITGB3ITGA2BKDM4EMEN1KMT2A | |
| SCHEMBL14224474 | 0.77 | MAPT (0.58) | KDM4EMEN1KMT2AGAAMAPT | |
| SCHEMBL14224479 | 0.77 | PTGER4 (0.57) | ITGB2ICAM1ITGALKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358267-B2 | Bis-aryl thiazole derivatives | AMGEN INC. (US) | 2008-04-15 | — | — | US | disclosed |