⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4075633 | 0.98 | THRB (0.31) | — | |
| Potassium SCHEMBL29519191 | 0.96 | — | — | |
| SCHEMBL18775436 | 0.79 | LMNA (0.33) | — | |
| SCHEMBL15910483 | 0.73 | — | — | |
| SCHEMBL4485232 | 0.71 | — | — | |
| SCHEMBL10445030 | 0.71 | — | — | |
| SCHEMBL10806666 | 0.67 | THRB (0.38) | — | |
| SCHEMBL21790201 | 0.67 | THRB (0.38) | — | |
| SCHEMBL8041239 | 0.67 | LMNA (0.50) | — | |
| SCHEMBL8040302 | 0.66 | LMNA (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820872-B1 | PYRROLO[1,2-B] PYRIDAZINE DERIVATIVES | GILEAD SCIENCES INC (US) | 2024-05-29 | — | — | EP | disclosed |
| CN-112566697-B | Pyrrolo [1,2-b ] pyridazine derivatives as IRAK4 inhibitors | 吉利德科学公司 | 2024-04-16 | — | — | CN | disclosed |
| CN-112566915-B | Thiadiazole IRAK4 inhibitors | 吉利德科学公司 | 2024-04-09 | — | — | CN | disclosed |
| US-20240109881-A1 | Heteroaryl Compounds as Ligand Directed Degraders of IRAK4 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-04-04 | — | — | US | disclosed |
| CN-117683034-A | Pyrrolo [1,2-B ] pyridazine derivatives | 吉利德科学公司 | 2024-03-12 | — | — | CN | disclosed |
| EP-3583105-B1 | PYRROLO [1,2-B]PYRIDAZINE DERIVATIVES | GILEAD SCIENCES INC (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2024020084-A1 | HETEROARYL COMPOUNDS AS LIGAND DIRECTED DEGRADERS OF IRAK4 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-01-25 | — | — | WO | disclosed |
| CN-112533924-B | Pyrrolo [1,2-b ] pyridazine derivatives as IRAK4 inhibitors | 吉利德科学公司 | 2023-11-28 | — | — | CN | disclosed |
| CN-112513044-B | Pyrrolo [1,2-B ] pyridazine derivatives | 吉利德科学公司 | 2023-11-07 | — | — | CN | disclosed |
| US-20230257386-A1 | PYRROLO[1,2-b]PYRIDAZINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-08-17 | — | — | US | disclosed |
| US-20030144307-A1 | 7-oxo-pyridopyrimidines (II) | ARZENO HUMBERTO BARTOLOME (US) | 2003-07-31 | — | — | US | disclosed |
| EP-1315726-A1 | 7- OXO PYRIDOPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-1315727-A2 | 7-OXO PYRIDOPYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-04 | — | — | EP | disclosed |
| US-6518276-B2 | Treating a p38 mediated disorders | SYNTEX (U.S.A.) LLC | 2003-02-11 | — | — | US | disclosed |
| US-6506749-B2 | Mitogen-activated protein kinases inhibitors | SYNTEX (U.S.A.) LLC | 2003-01-14 | — | — | US | disclosed |
| US-20020137756-A1 | Mitogen-activated protein kinases inhibitors | SYNTEX (U.S.A.) LLC | 2002-09-26 | — | — | US | disclosed |
| WO-2002064594-A2 | 6-SUBSTITUTED PYRIDO-PYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-22 | — | — | WO | disclosed |
| US-20020055513-A1 | 7-oxo-pyridopyrimidines (II) | SYNTEX (U.S.A.) LLC | 2002-05-09 | — | — | US | disclosed |
| WO-2002018379-A2 | 7-OXO PYRIDOPYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-07 | — | — | WO | disclosed |
| WO-2002018380-A1 | 7-OXO PYRIDOPYRIMIDINES AS INHIBITORS OF A CELLULAR PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-07 | — | — | WO | disclosed |