Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Guanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | PNP | P00491 | 4/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HBB | P68871 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanine SCHEMBL4658042 | 0.92 | ALDH1A1 (0.61) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL5259 | 0.92 | ALDH1A1 (0.61) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL27542045 | 0.90 | HSD17B10 (0.56) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL9512016 | 0.90 | ALDH1A1 (0.59) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL21611717 | 0.90 | ALDH1A1 (0.59) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL865492 | 0.90 | ALDH1A1 (0.59) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL28373862 | 0.90 | ALDH1A1 (0.59) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL2895087 | 0.90 | ALDH1A1 (0.59) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL4063556 | 0.90 | ALDH1A1 (0.59) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL27400536 | 0.90 | ALDH1A1 (0.59) | KDM4EALDH1A1LMNAGLAPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628558-B1 | Process for the synthesis of 9(2-hydroxyethoxy methyl) guanine | SOLAR CHEM SA (LU) | 1998-04-15 | — | — | EP | claimed |
| US-5496945-A | Process for the synthesis of 9-(2-hydroxyethoxy methyl) guanine | SOLAR CHEMICAL S.A. (LU) | 1996-03-05 | — | — | US | claimed |
| EP-0628558-A1 | Process for the synthesis of 9(2-hydroxyethoxy methyl) guanine | SOLAR CHEMICAL S.A. (LU) | 1994-12-14 | — | — | EP | claimed |
| JP-59027890-A | — | — | None | — | — | JP | disclosed |
| CN-112221527-B | N, S co-doped porous carbon-coated carbon nanotube bifunctional oxygen electrode catalyst and preparation method thereof | 大连理工大学 | 2021-08-20 | — | — | CN | disclosed |
| CN-112221527-A | N, S co-doped porous carbon-coated carbon nanotube bifunctional oxygen electrode catalyst and preparation method thereof | 大连理工大学 | 2021-01-15 | — | — | CN | disclosed |
| CN-109502571-A | A kind of preparation method of graphene-carbon nano tube composite material | 福州大学 | 2019-03-22 | — | — | CN | disclosed |
| CN-108864098-A | The method that one kind recycling guanine from 2,9- diacetylguanine centrifuge mother liquor | 江苏八巨药业有限公司 | 2018-11-23 | — | — | CN | disclosed |
| CN-100436590-C | Process for producing vitamin B6 | DSM IP ASSETS BV (NL) | 2008-11-26 | — | — | CN | disclosed |
| US-20080118926-A1 | Method For Detecting Methylation In Genes And Method For Examining Neoplasm Through Detecting Methylation In Genes | NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY (JP) | 2008-05-22 | — | — | US | disclosed |
| US-7371547-B2 | Process for producing vitamin B6 | DSM IP ASSETS B.V. (NL) | 2008-05-13 | — | — | US | disclosed |
| EP-1543138-B1 | PROCESS FOR PRODUCING VITAMIN B6 | DSM IP ASSETS BV (NL) | 2006-08-02 | — | — | EP | disclosed |
| CN-1685052-A | Production of vitamin B6Method (2) | DSM IP ASSETS BV (NL) | 2005-10-19 | — | — | CN | disclosed |
| EP-1543138-A2 | PROCESS FOR PRODUCING VITAMIN B6 | DSM IP Assets B.V. (NL) | 2005-06-22 | — | — | EP | disclosed |
| US-20050119411-A1 | Polymer composition | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 2005-06-02 | — | — | US | disclosed |
| WO-2004029270-A2 | PROCESS FOR PRODUCING VITAMIN B6 | DSM IP ASSETS B.V. (NL) | 2004-04-08 | — | — | WO | disclosed |
| EP-0628558-B1 | Process for the synthesis of 9(2-hydroxyethoxy methyl) guanine | SOLAR CHEM SA (LU) | 1998-04-15 | — | — | EP | disclosed |
| US-5496945-A | Process for the synthesis of 9-(2-hydroxyethoxy methyl) guanine | SOLAR CHEMICAL S.A. (LU) | 1996-03-05 | — | — | US | disclosed |
| EP-0628558-A1 | Process for the synthesis of 9(2-hydroxyethoxy methyl) guanine | SOLAR CHEMICAL S.A. (LU) | 1994-12-14 | — | — | EP | disclosed |
| JP-S5927890-A | PURIFICATION OF GUANINE | KOHJIN CO LTD | 1984-02-14 | — | — | JP | disclosed |