Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15942008 | 0.82 | CHRM2 (0.54) | L3MBTL1LMNASMN1; SMN2DRD4NOS2 | |
| SCHEMBL18711623 | 0.78 | DRD4 (0.47) | DRD4AOC3 | |
| SCHEMBL2453725 | 0.78 | LMNA (0.44) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL5456459 | 0.77 | LMNA (0.49) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL2450026 | 0.77 | LMNA (0.43) | L3MBTL1LMNAPOLBSMN1; SMN2HRH2 | |
| SCHEMBL20738510 | 0.76 | DRD4 (0.47) | POLBDRD4AOC3ALDH1A1TSHR | |
| SCHEMBL2454613 | 0.75 | LMNA (0.41) | L3MBTL1LMNAPOLBSMN1; SMN2HRH2 | |
| SCHEMBL2454067 | 0.75 | ALDH1A1 (0.43) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL4562941 | 0.75 | DRD4 (0.46) | SMN1; SMN2DRD4AOC3GRIN2BALDH1A1 | |
| SCHEMBL8922008 | 0.74 | CHRM4 (0.59) | L3MBTL1LMNAPOLBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004625-A2 | C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Vertex Pharmaceuticals Incorporated (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007111904-A2 | C-MET PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-04 | — | — | WO | disclosed |