Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2454613 | 0.83 | LMNA (0.41) | ALDH1A1CHRM2CHRM1LMNASMN1; SMN2 | |
| SCHEMBL2450026 | 0.82 | LMNA (0.43) | ALDH1A1CHRM2CHRM1LMNASMN1; SMN2 | |
| SCHEMBL2417525 | 0.80 | ALDH1A1 (0.50) | ALDH1A1LMNASMN1; SMN2KMT2ANPSR1 | |
| SCHEMBL2424923 | 0.80 | ALDH1A1 (0.50) | ALDH1A1HTTMAPTKDM4E | |
| SCHEMBL2453353 | 0.79 | SMN1; SMN2 (0.42) | ALDH1A1CHRM2CHRM1LMNASMN1; SMN2 | |
| SCHEMBL2444427 | 0.78 | LMNA (0.44) | ALDH1A1CHRM2CHRM1LMNASMN1; SMN2 | |
| SCHEMBL25131450 | 0.77 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2KMT2ANPSR1GAA | |
| SCHEMBL2453725 | 0.76 | LMNA (0.44) | ALDH1A1CHRM2CHRM1LMNASMN1; SMN2 | |
| SCHEMBL4831481 | 0.75 | L3MBTL1 (0.46) | ALDH1A1LMNASMN1; SMN2POLBMMP13 | |
| SCHEMBL2453898 | 0.74 | KMT2A (0.39) | ALDH1A1CHRM2CHRM1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2550252-A1 | 1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS | Theravance, Inc. (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119461-A1 | 1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS | THERAVANCE, INC. (US) | 2011-09-29 | — | — | WO | disclosed |