Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.46 |
| ▸ | HTR1A | P08908 | 8/20 | 0.46 |
| ▸ | DRD2 | P14416 | 8/20 | 0.46 |
| ▸ | DRD4 | P21917 | 8/20 | 0.46 |
| ▸ | HTR2A | P28223 | 8/20 | 0.46 |
| ▸ | HTR2C | P28335 | 8/20 | 0.46 |
| ▸ | HTR7 | P34969 | 8/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.46 |
| ▸ | HTR1D | P28221 | 7/20 | 0.46 |
| ▸ | DRD3 | P35462 | 7/20 | 0.46 |
| ▸ | HTR2B | P41595 | 7/20 | 0.46 |
| ▸ | DRD1 | P21728 | 6/20 | 0.46 |
| ▸ | DRD5 | P21918 | 6/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.46 |
| ▸ | HTR6 | P50406 | 6/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.46 |
| ▸ | HRH1 | P35367 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4838194 | 0.89 | MTNR1B (0.53) | OPRM1OPRL1OPRK1HTR1ADRD2 | |
| SCHEMBL4839599 | 0.88 | OPRM1 (0.48) | OPRM1OPRL1OPRK1HTR1ADRD2 | |
| SCHEMBL6670152 | 0.77 | OPRM1 (0.41) | OPRM1OPRL1OPRK1HTR1ADRD2 | |
| SCHEMBL4833277 | 0.76 | MTNR1B (0.61) | OPRM1OPRL1OPRK1DRD2DRD1 | |
| SCHEMBL4710045 | 0.70 | OPRM1 (0.72) | OPRM1OPRL1OPRK1HTR1ADRD2 | |
| SCHEMBL11735355 | 0.70 | OPRM1 (0.56) | OPRM1OPRL1OPRK1HTR1ADRD2 | |
| SCHEMBL3858986 | 0.70 | OPRM1 (0.65) | OPRM1OPRL1OPRK1HTR1ADRD2 | |
| SCHEMBL3850816 | 0.69 | OPRM1 (0.69) | OPRM1OPRL1OPRK1HTR1ADRD2 | |
| SCHEMBL14282239 | 0.68 | OPRM1 (0.76) | OPRM1OPRL1OPRK1HTR1ADRD2 | |
| SCHEMBL4833288 | 0.68 | NR1I2 (0.47) | OPRM1OPRL1OPRK1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384957-B2 | 3,4-dihydro-1H-isoquinolin-2-yl-derivatives | H. LUNDBECK A/S (DK) | 2008-06-10 | — | — | US | claimed |
| US-20050070713-A1 | 3 4-Dihydro-1h-isoquinoloin-2-yl-derivatives | H. LUNDBECK A/S (DK) | 2005-03-31 | — | — | US | claimed |
| US-7384957-B2 | 3,4-dihydro-1H-isoquinolin-2-yl-derivatives | H. LUNDBECK A/S (DK) | 2008-06-10 | — | — | US | disclosed |
| US-20050070713-A1 | 3 4-Dihydro-1h-isoquinoloin-2-yl-derivatives | H. LUNDBECK A/S (DK) | 2005-03-31 | — | — | US | disclosed |
| EP-1458714-A1 | 3,4-DIHYDRO-1H-ISOQUINOLOIN-2-YL-DERIVATIVES | H. Lundbeck A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051869-A1 | 3,4-DIHYDRO-1H-ISOQUINOLOIN-2-YL-DERIVATIVES | H. LUNDBECK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070713-A1 | 3 4-Dihydro-1h-isoquinoloin-2-yl-derivatives | KCNJ2, KCNK2, KCNJ11 | OPRM1 1618/4885OPRL1 480/4885OPRK1 271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.