SCHEMBL4833071

SCHEMBL4833071

COc1cc(CC(=O)O)ccc1OCCNC(=O)[C@@H]1Cc2ccccc2N1S(=O)(=O)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)cc1

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 8/20 0.40
PTGDR Q13258 4/20 0.40
PPARD Q03181 3/20 0.39
PPARG P37231 1/20 0.38
PPARA Q07869 1/20 0.38
GAA P10253 1/20 0.37
RXRA P19793 1/20 0.37
RXRB P28702 1/20 0.37
RXRG P48443 1/20 0.37
ALDH1A1 P00352 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
TBXA2R P21731 2/20 0.36
FFAR4 Q5NUL3 1/20 0.35
MMP8 P22894 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4845185 0.95 GAA (0.37) PTGDR2PTGDRPPARDGAAALDH1A1
SCHEMBL4845042 0.94 PPARD (0.41) PTGDR2PPARDPPARGPPARARXRA
SCHEMBL4838970 0.92 PPARD (0.39) PTGDR2PPARDPPARGPPARARXRA
SCHEMBL4838429 0.90 PPARD (0.36) PPARDPPARGPPARAALDH1A1FFAR4
SCHEMBL4841159 0.90 RORC (0.40) PTGDR2PTGDRMMP8
SCHEMBL4845420 0.90 FFAR4 (0.43) RXRARXRBRXRGALDH1A1FFAR4
SCHEMBL4841606 0.90 FFAR4 (0.43) RXRARXRBRXRGALDH1A1FFAR4
SCHEMBL4844578 0.89 RORC (0.35) PPARDALDH1A1FFAR4MMP8
SCHEMBL4842320 0.89 RXRA (0.41) PTGDR2PTGDRRXRARXRBRXRG
SCHEMBL4843247 0.86 FFAR4 (0.40) ALDH1A1SMN1; SMN2FFAR4MMP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7465811-B2 Indoline compounds LABORATOIRES FOURNIER S.A. (FR) 2008-12-16 US disclosed
US-20080119465-A1 Novel Indoline Compounds LABORATORIES FOURNIER S.A. (FR) 2008-05-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080119465-A1 Novel Indoline Compounds GPR119, INSR, IRS1 PTGDR2 2918/4885PTGDR 2137/4885PPARD 258/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.