Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.36 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 5/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11066170 | 0.85 | ADORA2A (0.50) | ADORA2AHDAC6HDAC1LTA4HADORA1 | |
| SCHEMBL13044929 | 0.80 | HDAC6 (0.47) | ADORA2AHDAC6HDAC1LTA4HADORA1 | |
| SCHEMBL3671304 | 0.78 | LTA4H (0.50) | ADORA2AHDAC6HDAC1LTA4H | |
| SCHEMBL13587965 | 0.78 | LTA4H (0.56) | ADORA2AHDAC6HDAC1LTA4HALDH1A1 | |
| SCHEMBL5635371 | 0.77 | LTA4H (0.49) | ADORA2AHDAC6HDAC1LTA4HMAPT | |
| SCHEMBL3487811 | 0.77 | HDAC6 (0.44) | ADORA2AHDAC6HDAC1LTA4HNPC1 | |
| SCHEMBL21591536 | 0.75 | LTA4H (0.48) | ADORA2AHDAC6HDAC1LTA4HMAPT | |
| SCHEMBL338773 | 0.75 | HDAC6 (0.52) | HDAC6HDAC1LTA4HKDM4EALDH1A1 | |
| SCHEMBL7109676 | 0.75 | LTA4H (0.48) | ADORA2AHDAC6HDAC1LTA4HMAPT | |
| SCHEMBL325140 | 0.74 | HDAC1 (0.61) | ADORA2AHDAC6HDAC1LTA4HPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4169717-A | METAL PROTEINATE AND GROWTH HORMONE | ASHMEAD H H | 1979-10-02 | — | — | US | claimed |
| US-20210253599-A1 | PROCESS FOR THE PREPARATION OF TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS FOR USING THE SAME FOR THE TREATMENT OF CANCER | GENENTECH, INC. | 2021-08-19 | — | — | US | disclosed |
| US-10900071-B2 | Identification of genetic modifications | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2021-01-26 | — | — | US | disclosed |
| US-10398695-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2019-09-03 | — | — | US | disclosed |
| US-20190040457-A1 | IDENTIFICATION OF GENETIC MODIFICATIONS | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2019-02-07 | — | — | US | disclosed |
| EP-3307755-A1 | IDENTIFICATION OF GENETIC MODIFICATIONS | Wake Forest University Health Sciences (US) | 2018-04-18 | — | — | EP | disclosed |
| WO-2016183289-A1 | IDENTIFICATION OF GENETIC MODIFICATIONS | WAKE FOREST UNIVERSITY HEALTH SERVICES (US) | 2016-11-17 | — | — | WO | disclosed |
| EP-2028272-B1 | METHOD OF MODIFYING NUCLEOTIDE CHAIN | PANASONIC CORP (JP) | 2014-01-08 | — | — | EP | disclosed |
| US-8129115-B2 | Method of modifying nucleotide chain | PANASONIC CORPORATION (JP) | 2012-03-06 | — | — | US | disclosed |
| US-7879863-B2 | Kallikrein inhibitors such as N-((2R)-3-methyl-2-{[4-(trifluoromethyl)phenyl]amino}butyl)-2-phenylacetamide trifluoroacetate, used for the treatment of gastrointestinal disorders, periodontal diseases, skin disorders, arthritis, hypotension, edema, respiratory system disorders and proliferative diseases | AJINOMOTO CO., INC. (JP) | 2011-02-01 | — | — | US | disclosed |
| US-20100291637-A1 | METHOD FOR MODIFYING NUCLEOTIDE CHAIN | PANASONIC CORPORATION (JP) | 2010-11-18 | — | — | US | disclosed |
| US-20100015670-A1 | METHOD OF MODIFYING NUCLEOTIDE CHAIN | PANASONIC CORPORATION (JP) | 2010-01-21 | — | — | US | disclosed |
| WO-2009147476-A1 | NOVEL PDE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | MATRIX LABORATORIES LTD. (IN) | 2009-12-10 | — | — | WO | disclosed |
| EP-1647592-B1 | METHOD OF MODIFYING NUCLEOTIDE CHAIN | PANASONIC CORP (JP) | 2009-03-11 | — | — | EP | disclosed |
| EP-2028272-A1 | METHOD OF MODIFYING NUCLEOTIDE CHAIN | Panasonic Corporation (JP) | 2009-02-25 | — | — | EP | disclosed |
| US-20070077629-A1 | Method for modifying nucleotide chain | PANASONIC CORPORATION (JP) | 2007-04-05 | — | — | US | disclosed |
| US-20070066586-A1 | ANILINE DERIVATIVES | AJINOMOTO CO., INC. (JP) | 2007-03-22 | — | — | US | disclosed |
| EP-1647592-A1 | METHOD OF MODIFYING NUCLEOTIDE CHAIN | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 2006-04-19 | — | — | EP | disclosed |
| US-4470840-A | WITH SOLVENT, COMPOUNDS 2A,2B,3, AND 4, AND PLANT GROWTH REGULATOR | BIOCHEMICAL RESEARCH CORPORATION (US) | 1984-09-11 | — | — | US | disclosed |
| US-4455162-A | POLAR SOLVENTS, METAL SALTS | BIOCHEMICAL RESEARCH CORPORATION (US) | 1984-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253599-A1 | PROCESS FOR THE PREPARATION OF TRICYCLIC PI3K INHIBITOR COMPOUNDS AND METHODS FOR USING THE SAME FOR THE TREATMENT OF CANCER | PIK3CA, PIK3CD, PIK3CB | ADORA2A 3011/4885HDAC6 881/4885HDAC1 871/4885 |
| US-20070066586-A1 | ANILINE DERIVATIVES | SERPINB1, ACE, REN | ADORA2A 1105/4885HDAC6 664/4885HDAC1 1060/4885 |
| US-10398695-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | PIK3CD, PIK3CA, PIK3CG | ADORA2A 3432/4885HDAC6 1189/4885HDAC1 897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.