Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.40 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CHKA | P35790 | 1/20 | 0.34 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1171254 | 0.84 | HTR2C (0.43) | HTR2CHTR2BCHRNB2CHRNA4CHKA | |
| SCHEMBL1171350 | 0.83 | HTR2C (0.43) | HTR2CHTR2BCHRNB2CHRNA4CHKA | |
| SCHEMBL4762733 | 0.81 | ALDH1A1 (0.42) | NPC1ALDH1A1TP53RAB9A | |
| SCHEMBL4764501 | 0.78 | CYP11B2 (0.34) | HTR2C | |
| SCHEMBL29935595 | 0.75 | HTR2C (0.46) | HTR2CHTR2BHTR2A | |
| SCHEMBL4791331 | 0.74 | ACHE (0.40) | ACHETP53MAPTTHRB | |
| SCHEMBL1171271 | 0.70 | L3MBTL3 (0.46) | L3MBTL1 | |
| SCHEMBL15533052 | 0.70 | OGA (0.39) | HTR2CHTR2BHTR2A | |
| SCHEMBL4793745 | 0.69 | CHKA (0.38) | HTR2CHTR2BCHKAHTR2AKDM4E | |
| SCHEMBL1171285 | 0.69 | ALDH1A1 (0.34) | CHKAKDM4EMEN1NPC1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899350-A1 | PYRAZOLO Ý3 , 4-D¨AZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007025596-A1 | PYRAZOLO [3 , 4-D] AZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2007-03-08 | — | — | WO | disclosed |