Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4848007 | 0.78 | ALDH1A1 (0.53) | CHRNB2CHRNA4MCHR1 | |
| SCHEMBL15217040 | 0.74 | CHRNB2 (0.49) | CHRNB2CHRNA4CHRNB4CHRNA3PARP1 | |
| SCHEMBL2227813 | 0.74 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL23060637 | 0.74 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2227430 | 0.74 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL7094041 | 0.73 | CHRNA7 (0.56) | PARP1 | |
| SCHEMBL4839016 | 0.73 | CHRNA7 (0.56) | PARP1 | |
| SCHEMBL19281800 | 0.73 | CYP1A2 (0.40) | IRAK4 | |
| SCHEMBL5041622 | 0.73 | CHRNB2 (0.60) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5370480 | 0.73 | CHRNB2 (0.60) | CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329754-B2 | 2,5-diazabicyclo[2.2.1]heptane derivatives | NEUROSEARCH A/S (DK) | 2008-02-12 | — | — | US | claimed |
| EP-1368348-B1 | NOVEL 2,5-DIAZABICYCLO(2.2.1)HEPTANE DERIVATIVES | NEUROSEARCH AS (DK) | 2005-01-19 | — | — | EP | claimed |
| US-20040181069-A1 | Novel 2,5-diazabicyclo[2.2.1]heptane derivatives | DANPET AB (SE) | 2004-09-16 | — | — | US | claimed |
| EP-1368348-A1 | NOVEL 2,5-DIAZABICYCLO(2.2.1)HEPTANE DERIVATIVES | NEUROSEARCH A/S (DK) | 2003-12-10 | — | — | EP | claimed |
| WO-2002070522-A1 | NOVEL 2,5-DIAZABICYCLO[2.2.1]HEPTANE DERIVATIVES | NEUROSEARCH A/S (DK) | 2002-09-12 | — | — | WO | claimed |
| US-7329754-B2 | 2,5-diazabicyclo[2.2.1]heptane derivatives | NEUROSEARCH A/S (DK) | 2008-02-12 | — | — | US | disclosed |
| EP-1368348-B1 | NOVEL 2,5-DIAZABICYCLO(2.2.1)HEPTANE DERIVATIVES | NEUROSEARCH AS (DK) | 2005-01-19 | — | — | EP | disclosed |
| US-20040181069-A1 | Novel 2,5-diazabicyclo[2.2.1]heptane derivatives | DANPET AB (SE) | 2004-09-16 | — | — | US | disclosed |
| EP-1368348-A1 | NOVEL 2,5-DIAZABICYCLO(2.2.1)HEPTANE DERIVATIVES | NEUROSEARCH A/S (DK) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002070522-A1 | NOVEL 2,5-DIAZABICYCLO[2.2.1]HEPTANE DERIVATIVES | NEUROSEARCH A/S (DK) | 2002-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040181069-A1 | Novel 2,5-diazabicyclo[2.2.1]heptane derivatives | CHRNA2, CHRNB2, CHRNA10 | CSNK1E 2734/4885IRAK4 1768/4885CHRNB2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.