N4-Hydroxycytosine

N4-Hydroxycytosine

SCHEMBL48396

O=c1nc(NO)cc[nH]1

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28619339 0.83 DYRK1A (0.32)
SCHEMBL27952254 0.77 NCF1 (0.39)
SCHEMBL11894063 0.77
SCHEMBL4492969 0.77
SCHEMBL3133642 0.77
SCHEMBL5985571 0.77
SCHEMBL7876670 0.77
SCHEMBL8944768 0.77
SCHEMBL19692379 0.77
SCHEMBL4726446 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 266 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2026-05-28 US claimed
WO-2025038971-A1 OLIGONUCLEOTIDES CONTAINING A LIGAND AT A NUCLEOBASE, 2' POSITION, OR 3' POSITION ADARX PHARMACEUTICALS, INC. (US) 2025-02-20 WO claimed
EP-4508037-A1 CARBOBICYCLIC NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTION The Chinese University of Hong Kong (HK) 2025-02-19 EP claimed
CN-119125384-A Method for determining concentration of Mo Nuola-pyrrosid and/or active metabolite beta-d-N4-hydroxycytosine in human body fluid based on liquid chromatography-mass spectrometry after chemical derivatization of benzoyl chloride 中国人民解放军海军军医大学第一附属医院 2024-12-13 CN claimed
CN-118086264-A Cytidine deaminase immobilization based on T4 phage-bound magnetic bead composite material 江苏海洋大学 2024-05-28 CN claimed
US-20240139325-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2024-05-02 US claimed
CN-117881403-A Thionucleosides as antiviral agents 爱莫里大学 2024-04-12 CN claimed
CN-117858710-A Method for treating veterinary viral diseases 英特维特国际股份有限公司 2024-04-09 CN claimed
CN-117858711-A Nucleoside and nucleotide analogs as antiviral agents 爱莫里大学 2024-04-09 CN claimed
CN-117512078-A Single primer to double primer amplicon conversion 西格马-奥尔德里奇有限责任公司 2024-02-06 CN claimed
WO-2018057846-A1 SINGLE PRIMER TO DUAL PRIMER AMPLICON SWITCHING SIGMA-ALDRICH CO, LLC (US) 2018-03-29 WO claimed
CN-107427529-A N4-hydroxycytidine and derivatives and antiviral uses related thereto 埃莫里大学 2017-12-01 CN claimed
US-20160333340-A1 COMPOSITIONS AND METHODS FOR NUCLEIC ACID AMPLIFICATION Twist Bioscience Corporation 2016-11-17 US claimed
WO-2016183100-A1 COMPOSITIONS AND METHODS FOR NUCLEIC ACID AMPLIFICATION Twist Bioscience Corporation (US) 2016-11-17 WO claimed
WO-2008033432-A2 IMMUNE MODULATION BY CHEMICALLY MODIFIED RIBONUCLEOSIDES AND OLIGORIBONUCLEOTIDES COLEY PHARMACEUTICAL GROUP, INC. (US) 2008-03-20 WO claimed
US-5817799-A 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1998-10-06 US claimed
EP-0540686-B1 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES US COMMERCE (US) 1995-08-30 EP claimed
EP-0540686-A4 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES US COMMERCE (US) 1993-05-26 EP claimed
EP-0540686-A1 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES. US COMMERCE (US) 1993-05-12 EP claimed
WO-1992001700-A1 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, U.S. DEPARTMENT OF COMMERCE (US) 1992-02-06 WO claimed