SCHEMBL5985571

SCHEMBL5985571

O=c1nc(NF)cc[nH]1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4726446 0.77
SCHEMBL19692379 0.77
N4-Hydroxycytosine SCHEMBL48396 0.77
SCHEMBL27952254 0.77 NCF1 (0.39)
SCHEMBL4492969 0.77
SCHEMBL7876670 0.77
SCHEMBL11894063 0.77
SCHEMBL8944768 0.77
SCHEMBL3133642 0.77
SCHEMBL17372301 0.77 ALDH1A1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117538474-A Method for detecting DNA demethylation by combining metabolic marker with LC-MS and application thereof 中国水产科学研究院南海水产研究所 2024-02-09 CN claimed
CN-101868254-B Positron emission tomography probes for imaging immune activation and selected cancers UNIV CALIFORNIA 2013-08-21 CN claimed
CN-101868254-A The positron emission transaxial tomography probe that immune activation and selected cancers imaging are used UNIV CALIFORNIA 2010-10-20 CN claimed
EP-0898575-B1 A COMBINATORIAL PROTECTING GROUP STRATEGY FOR MULTIFUNCTIONAL MOLECULES KOESTER HUBERT DR (US) 2004-12-29 EP claimed
CN-117538474-A Method for detecting DNA demethylation by combining metabolic marker with LC-MS and application thereof 中国水产科学研究院南海水产研究所 2024-02-09 CN disclosed
CN-117538474-A Method for detecting DNA demethylation by combining metabolic marker with LC-MS and application thereof 中国水产科学研究院南海水产研究所 2024-02-09 CN disclosed
US-20230227834-A1 Plasmid Copy Number Regulation and Integration BASF SE (DE) 2023-07-20 US disclosed
US-20230173076-A1 METABOLICALLY STABLE PEPTIDE ANALOGS UNIV STRASBOURG (FR) 2023-06-08 US disclosed
EP-4168557-A1 PLASMID COPY NUMBER REGULATION AND INTEGRATION BASF SE (DE) 2023-04-26 EP disclosed
CN-113185466-B Novel low-carbon-emission flucytosine production process 宿迁市万和泰化工有限公司 2022-09-06 CN disclosed
WO-2022117745-A1 ANTISENSE OLIGONUCLEOTIDES TARGETING ATXN3 F. HOFFMANN-LA ROCHE AG (CH) 2022-06-09 WO disclosed
US-10995075-B2 Process for producing fluorocytosine and fluorocytosine derivatives UNIVERSITY OF DURHAM 2021-05-04 US disclosed
CN-103974724-A Modified nucleosides, nucleotides and nucleic acids and uses thereof modeRNA Therapeutics 2014-08-06 CN disclosed
CN-101861168-B Anti-ICOS antibodies and their use in treatment of oncology, transplantation and autoimmune disease MEDIMMUNE LLC 2014-07-02 CN disclosed
CN-101868254-B Positron emission tomography probes for imaging immune activation and selected cancers UNIV CALIFORNIA 2013-08-21 CN disclosed
CN-101868254-A The positron emission transaxial tomography probe that immune activation and selected cancers imaging are used UNIV CALIFORNIA 2010-10-20 CN disclosed
CN-101861168-A Anti-ICOS antibodies and their use in treatment of oncology, transplantation and autoimmune disease MEDIMMUNE LLC 2010-10-13 CN disclosed
EP-1706414-A2 PROCESS FOR FLUOROCYTIDINE DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 2006-10-04 EP disclosed
CN-1833020-A Pro104 antibody compositions and methods of use DIADEXUS INC (US) 2006-09-13 CN disclosed
WO-2005063786-A2 PROCESS FOR FLUOROCYTIDINE DERIVATIVES F.HOFFMAN-LA ROCHE AG (CH) 2005-07-14 WO disclosed