Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772225 | 0.80 | TAAR1 (0.47) | — | |
| SCHEMBL4765824 | 0.73 | TAAR1 (0.51) | — | |
| SCHEMBL1579468 | 0.71 | KDM4E (0.42) | — | |
| SCHEMBL5482947 | 0.71 | CYP3A4 (0.41) | — | |
| SCHEMBL8229273 | 0.70 | GAA (0.44) | POLBPTPN1 | |
| SCHEMBL4374020 | 0.70 | LMNA (0.45) | POLB | |
| SCHEMBL27749404 | 0.69 | ALDH1A1 (0.32) | — | |
| SCHEMBL4777916 | 0.68 | POLB (0.33) | POLBPTPN1 | |
| SCHEMBL17653319 | 0.66 | HTR2A (0.44) | POLB | |
| SCHEMBL14340999 | 0.66 | S1PR5 (0.35) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991531-A1 | CINNOLINE AND QUINOXALINE DERIVATES AS PHOSPHODIESTERASE 10 INHIBITORS | Amgen Inc. (US) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007100880-A1 | CINNOLINE AND QUINAZOLINE DERIVATES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2007-09-07 | — | — | WO | disclosed |