Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | CCR4 | P51679 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4842636 | 0.82 | DGAT2 (0.33) | PTGS2PTGS1L3MBTL1DGAT2PDE2A | |
| SCHEMBL4841715 | 0.80 | DGAT2 (0.32) | PTGS2PTGS1L3MBTL1DGAT2PDE2A | |
| SCHEMBL4841726 | 0.80 | DGAT2 (0.36) | PTGS2PTGS1L3MBTL1DGAT2 | |
| SCHEMBL4842631 | 0.80 | L3MBTL1 (0.34) | PTGS2L3MBTL1DGAT2PDE2APDE10A | |
| SCHEMBL4837740 | 0.80 | SCN9A (0.36) | CNR1CNR2DGAT2PDE2APDE10A | |
| SCHEMBL14018946 | 0.76 | SCN9A (0.34) | DGAT2PDE2APDE10ASCN9A | |
| SCHEMBL4833086 | 0.76 | SCN9A (0.34) | DGAT2PDE2APDE10ASCN9A | |
| SCHEMBL4845291 | 0.72 | MAPK14 (0.39) | CNR1CNR2DGAT2 | |
| SCHEMBL4841381 | 0.72 | MAPK14 (0.40) | CNR1CNR2DGAT2 | |
| SCHEMBL14018955 | 0.72 | MAPK14 (0.44) | PTGS2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435731-B2 | Substituted pyrazolo[3,4-d]pyrimadines and methods of using the same | ROCHE PALO ALTO LLC (US) | 2008-10-14 | — | — | US | disclosed |