Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 4/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.30 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4841726 | 0.85 | DGAT2 (0.36) | DGAT2PTGS2PTGS1L3MBTL1 | |
| SCHEMBL4841715 | 0.83 | DGAT2 (0.32) | DGAT2PTGS2PTGS1PDE2APDE10A | |
| SCHEMBL4841759 | 0.82 | PTGS2 (0.34) | DGAT2PTGS2PTGS1SCN9APDE2A | |
| SCHEMBL14018946 | 0.79 | SCN9A (0.34) | DGAT2SCN9APDE2APDE10A | |
| SCHEMBL4833086 | 0.79 | SCN9A (0.34) | DGAT2SCN9APDE2APDE10A | |
| SCHEMBL4842631 | 0.78 | L3MBTL1 (0.34) | DGAT2PTGS2SCN9APDE2APDE10A | |
| SCHEMBL4837740 | 0.76 | SCN9A (0.36) | DGAT2SCN9APDE2APDE10A | |
| SCHEMBL14018795 | 0.72 | CXCR2 (0.38) | DGAT2 | |
| SCHEMBL4833090 | 0.72 | CXCR2 (0.38) | DGAT2 | |
| SCHEMBL4840856 | 0.71 | MAPK14 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435731-B2 | Substituted pyrazolo[3,4-d]pyrimadines and methods of using the same | ROCHE PALO ALTO LLC (US) | 2008-10-14 | — | — | US | claimed |
| US-20050197340-A1 | Fused-pyrazolo pyrimidine and pyrazolo pyrimidinone derivatives and methods for using the same | ROCHE PALO ALTO LLC | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197340-A1 | Fused-pyrazolo pyrimidine and pyrazolo pyrimidinone derivatives and methods for using the same | MAP3K1, MAPK1, MAP3K8 | DGAT2 4662/4885PTGS2 964/4885PTGS1 685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.