Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4842636 | 0.85 | DGAT2 (0.33) | DGAT2PTGS2PTGS1L3MBTL1 | |
| SCHEMBL4841715 | 0.81 | DGAT2 (0.32) | DGAT2PTGS2PTGS1L3MBTL1 | |
| SCHEMBL4841759 | 0.80 | PTGS2 (0.34) | DGAT2PTGS2PTGS1L3MBTL1 | |
| SCHEMBL4842631 | 0.78 | L3MBTL1 (0.34) | DGAT2PTGS2L3MBTL1LMNA | |
| SCHEMBL4833086 | 0.77 | SCN9A (0.34) | DGAT2MAOALMNA | |
| SCHEMBL14018946 | 0.77 | SCN9A (0.34) | DGAT2MAOALMNA | |
| SCHEMBL4837740 | 0.76 | SCN9A (0.36) | DGAT2MAOALMNA | |
| SCHEMBL4840924 | 0.73 | MAPK14 (0.49) | DGAT2PTGS2 | |
| SCHEMBL14018955 | 0.71 | MAPK14 (0.44) | PTGS2 | |
| SCHEMBL4832594 | 0.71 | MAPK14 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435731-B2 | Substituted pyrazolo[3,4-d]pyrimadines and methods of using the same | ROCHE PALO ALTO LLC (US) | 2008-10-14 | — | — | US | disclosed |