Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407899 | 0.91 | HPGD (0.56) | HPGDRECQLPTPN2PTPN1PTPN6 | |
| SCHEMBL3730650 | 0.86 | HPGD (0.51) | HPGDRECQLPTPN2PTPN1PTPN6 | |
| SCHEMBL23727040 | 0.86 | HPGD (0.58) | HPGDRECQLPTPN2PTPN1PTPN6 | |
| SCHEMBL18519692 | 0.86 | HPGD (0.58) | HPGDRECQLPTPN2PTPN1PTPN6 | |
| SCHEMBL227336 | 0.84 | HPGD (0.55) | HPGDRECQLPTPN2PTPN1PTPN6 | |
| SCHEMBL586312 | 0.83 | HPGD (0.54) | HPGDRECQLPTPN2PTPN1PTPN6 | |
| SCHEMBL389962 | 0.83 | HPGD (0.54) | HPGDRECQLPTPN2PTPN1PTPN6 | |
| SCHEMBL894559 | 0.83 | HPGD (0.54) | HPGDRECQLPTPN2PTPN1PTPN6 | |
| SCHEMBL27618591 | 0.80 | GPR119 (0.52) | HPGDRECQLGPR119EPHX1USP2 | |
| SCHEMBL2657012 | 0.78 | HPGD (0.57) | HPGDRECQLPTPN2PTPN1PTPN6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996583-A1 | THIAZOLES AS NF-KB INHIBITORS (PROTEASOME INHIBITORS) | 4SC AG (DE) | 2008-12-03 | — | — | EP | disclosed |
| EP-1994017-A2 | NOVEL HETEROCYCLIC NF-KB INHIBITORS | 4SC AG (DE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007104557-A2 | NOVEL HETEROCYCLIC NF-KB INHIBITORS | 4SC AG (DE) | 2007-09-20 | — | — | WO | disclosed |
| WO-2007104558-A1 | THIAZOLES AS NF-KB INHIBITORS (PROTEASOME INHIBITORS) | 4SC AG (DE) | 2007-09-20 | — | — | WO | disclosed |