Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 10/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.56 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.49 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5342329 | 0.85 | SMN1; SMN2 (0.84) | SMN1; SMN2NPC1RAB9ACYP1A2KDM4E | |
| SCHEMBL16277788 | 0.81 | LMNA (0.56) | SMN1; SMN2NPC1RAB9ACYP17A1CYP3A4 | |
| SCHEMBL26768653 | 0.80 | SMN1; SMN2 (1.00) | SMN1; SMN2NPC1RAB9ACYP1A2KDM4E | |
| SCHEMBL3737508 | 0.80 | CYP11B2 (0.55) | NPC1RAB9ACYP11B2CYP11B1CYP17A1 | |
| SCHEMBL31055739 | 0.79 | SMN1; SMN2 (0.74) | SMN1; SMN2NPC1RAB9ACYP1A2KDM4E | |
| SCHEMBL29853676 | 0.79 | SMN1; SMN2 (0.79) | SMN1; SMN2NPC1RAB9ACYP1A2KDM4E | |
| SCHEMBL7267474 | 0.79 | SMN1; SMN2 (0.79) | SMN1; SMN2NPC1RAB9ACYP1A2KDM4E | |
| SCHEMBL16446303 | 0.79 | CYP11B2 (0.74) | SMN1; SMN2NPC1RAB9ACYP11B2CYP11B1 | |
| SCHEMBL28439295 | 0.79 | KMO (0.64) | NPC1RAB9ACYP19A1KDM4EALDH1A1 | |
| SCHEMBL20118972 | 0.78 | KDM4E (0.53) | SMN1; SMN2NPC1RAB9ACYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423030-B2 | 1-amino-phthalazine derivatives, the preparation and the therapeutic use thereof | SANOFI-AVENTIS (FR) | 2008-09-09 | — | — | US | disclosed |
| US-20070099895-A1 | 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099895-A1 | 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF | CYP11B2, CYP11B1, GOT2 | SMN1; SMN2 1239/4885NPC1 204/4885RAB9A 3275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.