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SCHEMBL4842487

SCHEMBL4842487

CC(C)(C)OC(=O)CC(N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)OC(C)(C)C

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ TACR1 P25103 2/20 0.56
▸ CTSL P07711 2/20 0.55
▸ CTSS P25774 1/20 0.55
▸ CTSK P43235 1/20 0.55
▸ MAPT P10636 2/20 0.53
▸ TP53 P04637 1/20 0.53
▸ SMN1; SMN2 Q16637 1/20 0.51
▸ ACE P12821 3/20 0.51
▸ REN P00797 1/20 0.50
▸ MEN1 O00255 1/20 0.50
▸ HCRTR1 O43613 1/20 0.50
▸ KMT2A Q03164 1/20 0.50
▸ IL1RN P18510 1/20 0.49
▸ ECE1 P42892 1/20 0.49
▸ CCKBR P32239 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30311151 0.92 ACE (0.61) CTSLCTSSCTSKACEECE1
SCHEMBL16463539 0.88 TACR1 (0.60) TACR1CTSLCTSSCTSKMAPT
SCHEMBL16463542 0.88 TACR1 (0.60) TACR1CTSLCTSSCTSKMAPT
SCHEMBL4068546 0.87 CTSL (0.56) TACR1CTSLCTSSCTSKMAPT
SCHEMBL4842426 0.85 TACR1 (0.55) TACR1CTSLCTSSCTSKMAPT
SCHEMBL9966747 0.82 MEN1 (0.60) TACR1CTSLCTSSCTSKMAPT
SCHEMBL30406730 0.82 TACR1 (0.66) TACR1CTSLCTSSCTSKMAPT
SCHEMBL9331123 0.82 MAPT (0.55) TACR1CTSLCTSSCTSKMAPT
SCHEMBL28043198 0.82 KMT2A (0.61) MAPTMEN1HCRTR1KMT2AIL1RN
SCHEMBL17534495 0.82 MEN1 (0.61) MAPTACEMEN1HCRTR1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7365091-B2 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX ENOBIA PHARMA (CA) 2008-04-29 — — US disclosed
US-20060287280-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX ENOBIA PHARMA (CA) 2006-12-21 — — US disclosed
US-7105539-B2 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex ENOBIA PHARMA (CA) 2006-09-12 — — US disclosed
US-20060135480-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex ENOBIA PHARMA (CA) 2006-06-22 — — US disclosed
US-20040186301-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex BIOMEP INC. 2004-09-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060287280-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of PHEX GLS, SUCNR1, PGD TACR1 3920/4885CTSL 2006/4885CTSS 1630/4885
US-20040186301-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex GLS, SUCNR1, PGD TACR1 3994/4885CTSL 2180/4885CTSS 1756/4885
US-20060135480-A1 Derivatives of succinic and glutaric acids and analogs thereof useful as inhibitors of phex GLS, SUCNR1, GCDH TACR1 4027/4885CTSL 2287/4885CTSS 1908/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.