Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17342587 | 0.89 | ALDH1A1 (0.48) | MAPTLMNAALDH1A1RAB9ATP53 | |
| SCHEMBL12407192 | 0.86 | ALDH1A1 (0.53) | MAPTLMNAALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL14466318 | 0.84 | MAPT (0.51) | MAPTLMNAALDH1A1RAB9ATP53 | |
| SCHEMBL17346687 | 0.84 | MAPT (0.51) | MAPTLMNAALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL10639437 | 0.83 | RAB9A (0.50) | MAPTLMNAALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL10677828 | 0.83 | RAB9A (0.52) | MAPTRAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL10912953 | 0.82 | CTSK (0.52) | MAPTRAB9ASMN1; SMN2NPC1CASP3 | |
| SCHEMBL18353145 | 0.82 | LMNA (0.49) | MAPTLMNAALDH1A1RAB9ATP53 | |
| SCHEMBL750595 | 0.82 | MAPT (0.49) | MAPTLMNAALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL18355346 | 0.82 | LMNA (0.46) | MAPTLMNAALDH1A1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445502-B2 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS | ALKERMES PHARMA IRELAND LTD (IE) | 2022-09-28 | — | — | EP | disclosed |
| EP-1940785-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SmithKline Beecham Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007030761-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |