Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GUSB | P08236 | 2/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 3/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | HPN | P05981 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4841890 | 0.88 | PTGES (0.46) | PTGESHPGDHDAC3HDAC7HDAC10 | |
| Trifluoroacetic Acid SCHEMBL4843458 | 0.85 | PDE5A (0.43) | GUSBHSD17B10HDAC6PDE5ACCNB2 | |
| SCHEMBL4844661 | 0.80 | PDE5A (0.37) | PTGESGUSBHDAC3HDAC7HDAC10 | |
| Trifluoroacetic Acid SCHEMBL4843644 | 0.79 | PIN1 (0.49) | HDAC3HDAC6MGAM | |
| Trifluoroacetic Acid SCHEMBL5260040 | 0.77 | ALDH1A1 (0.48) | KDM4EHPGDHSD17B10HDAC6ALDH1A1 | |
| SCHEMBL13607846 | 0.76 | PTGES (0.55) | PTGESHPGDHDAC6MGAMCDK1 | |
| Trifluoroacetic Acid SCHEMBL4841475 | 0.76 | DYRK1B (0.38) | HDAC6CCNB2CDK1CCNB1GSK3B | |
| Trifluoroacetic Acid SCHEMBL4834909 | 0.76 | HDAC6 (0.47) | KDM4EHPGDHDAC3HDAC6ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4842729 | 0.76 | AURKA (0.52) | KDM4EGUSBCCNB2CDK1CCNB1 | |
| Trifluoroacetic Acid SCHEMBL4842876 | 0.76 | CHEK2 (0.45) | KDM4EGUSBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7410966-B2 | Use of and some novel imidazopyridines | ASTRAZENECA AB (SE) | 2008-08-12 | — | — | US | disclosed |
| EP-1539759-B1 | NOVEL IMIDAZOPYRIDINES AND THEIR USE | ASTRAZENECA AB (SE) | 2007-08-15 | — | — | EP | disclosed |
| US-20050261333-A1 | Use of and some novel imidazopyridines | ASTRAZENECA A B (SE) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261333-A1 | Use of and some novel imidazopyridines | ITK, CSNK1A1, RPS6KA1 | PTGES 1862/4885KDM4E 2903/4885HPGD 1597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.