Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | TP53 | P04637 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | MMP9 | P14780 | 3/20 | 0.43 |
| ▸ | MMP8 | P22894 | 3/20 | 0.43 |
| ▸ | MMP13 | P45452 | 3/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23999983 | 0.92 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4ETP53HSD17B10 | |
| Trifluoroacetic Acid SCHEMBL4842876 | 0.84 | CHEK2 (0.45) | ALDH1A1KDM4ENPC1RAB9AMMP2 | |
| Trifluoroacetic Acid SCHEMBL4842729 | 0.84 | AURKA (0.52) | KDM4ENPC1MAPTRAB9AMMP2 | |
| Trifluoroacetic Acid SCHEMBL4834909 | 0.84 | HDAC6 (0.47) | ALDH1A1HPGDKDM4ETP53MAPT | |
| Trifluoroacetic Acid SCHEMBL4838856 | 0.83 | TBK1 (0.43) | MEN1KMT2ANPC1RAB9APTGS2 | |
| Trifluoroacetic Acid SCHEMBL4845932 | 0.82 | DGAT1 (0.45) | MMP2MMP9MMP8MMP13HDAC6 | |
| Trifluoroacetic Acid SCHEMBL4835232 | 0.81 | HDAC3 (0.50) | MMP2MMP9MMP8MMP13HDAC1 | |
| Trifluoroacetic Acid SCHEMBL4846619 | 0.81 | MMP2 (0.35) | TP53KMT2ANPC1MAPTRAB9A | |
| SCHEMBL5260047 | 0.80 | MMP2 (0.41) | ALDH1A1HPGDKDM4ENPC1MAPT | |
| Trifluoroacetic Acid SCHEMBL4845670 | 0.79 | FFAR1 (0.42) | HDAC1HPSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539759-B1 | NOVEL IMIDAZOPYRIDINES AND THEIR USE | ASTRAZENECA AB (SE) | 2007-08-15 | — | — | EP | disclosed |