Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.36 |
| ▸ | LIPE | Q05469 | 8/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14254710 | 1.00 | KCNN3 (0.36) | KCNN3LIPEMETAP2MAPTHCRTR1 | |
| SCHEMBL4848707 | 1.00 | KCNN3 (0.36) | KCNN3LIPEMETAP2MAPTHCRTR1 | |
| SCHEMBL4841746 | 0.92 | METAP2 (0.39) | LIPEMETAP2HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL14254856 | 0.92 | METAP2 (0.39) | LIPEMETAP2HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL14254709 | 0.89 | GRM2 (0.37) | KCNN3LIPEHCRTR1HCRTR2CYP3A4 | |
| SCHEMBL4847817 | 0.89 | KCNN3 (0.38) | KCNN3LIPEMETAP2HCRTR1HCRTR2 | |
| SCHEMBL6478244 | 0.88 | KCNN3 (0.34) | KCNN3LIPEMETAP2MAPTHCRTR1 | |
| SCHEMBL14254846 | 0.86 | GCGR (0.35) | KCNN3LIPEMETAP2MAPTHCRTR1 | |
| SCHEMBL14254843 | 0.86 | KCNN3 (0.34) | KCNN3LIPEMETAP2HCRTR1HCRTR2 | |
| SCHEMBL6477360 | 0.86 | GCGR (0.35) | KCNN3LIPEMETAP2GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342012-B2 | Inhibitors of αLβ2 mediated cell adhesion | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-03-11 | — | — | US | disclosed |
| US-20050148602-A1 | Inhibitors of alphaLbeta2 mediated cell adhesion | TANABE SEIYAKU CO., LTD. | 2005-07-07 | — | — | US | disclosed |
| US-6897225-B1 | Inhibitors of αLβ2 mediated cell adhesion | TANABE SEIYAKU CO., LTD. (JP) | 2005-05-24 | — | — | US | disclosed |
| EP-1307455-B1 | INHIBITORS OF ALPHA-L BETA-2 MEDIATED CELL ADHESION | TANABE SEIYAKU CO (JP) | 2005-04-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148602-A1 | Inhibitors of alphaLbeta2 mediated cell adhesion | ITGB2, ITGA2B, ITGB1 | KCNN3 989/4885LIPE 3225/4885METAP2 1571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.