Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | RARA | P10276 | 2/20 | 0.46 |
| ▸ | RARB | P10826 | 2/20 | 0.46 |
| ▸ | RARG | P13631 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732214 | 0.85 | MEN1 (0.50) | MAPK1POLBKMT2AMEN1PKM | |
| SCHEMBL3341333 | 0.82 | KMT2A (0.42) | MAPK1KMT2AMEN1PKMNPSR1 | |
| SCHEMBL4732495 | 0.78 | MAPT (0.56) | MAPK1POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL3337610 | 0.74 | KMT2A (0.59) | MAPK1POLBKMT2AMEN1PKM | |
| SCHEMBL11674649 | 0.71 | CRHBP (0.59) | MAPK1POLBKMT2AMEN1NPSR1 | |
| Ammonia Solution, Strong SCHEMBL8550166 | 0.68 | ALDH1A1 (0.51) | MAPK1KMT2AMEN1PKMNPSR1 | |
| SCHEMBL11135292 | 0.68 | ALDH1A1 (0.62) | MAPK1POLBKMT2AMEN1NPSR1 | |
| SCHEMBL3341845 | 0.68 | MAPT (0.60) | MAPK1POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL28723024 | 0.68 | CES1 (0.66) | MAPK1POLBKMT2AMEN1NPSR1 | |
| SCHEMBL9805952 | 0.67 | POLB (1.00) | MAPK1POLBKMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | disclosed |