Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.45 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.45 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.45 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.45 |
| ▸ | CBFB | Q13951 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | WNT1 | P04628 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4847239 | 0.77 | CHRNA7 (0.46) | KDM4EPARP1CHRNA7KCNH2 | |
| SCHEMBL4846555 | 0.75 | ALDH1A1 (0.51) | HTR1APARP1CHRNA7KCNH2ALDH1A1 | |
| SCHEMBL5873534 | 0.68 | MCHR1 (0.56) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL5873663 | 0.68 | MCHR1 (0.63) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL2175124 | 0.68 | NPC1 (0.67) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL17432454 | 0.68 | KDM4E (0.65) | KDM4EMEN1NPC1MAPTRAB9A | |
| SCHEMBL5873575 | 0.68 | MCHR1 (0.55) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL5873688 | 0.68 | MCHR1 (0.55) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL5873704 | 0.68 | MCHR1 (0.62) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL5873481 | 0.68 | MCHR1 (0.55) | MEN1NPC1RAB9AKMT2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329754-B2 | 2,5-diazabicyclo[2.2.1]heptane derivatives | NEUROSEARCH A/S (DK) | 2008-02-12 | — | — | US | claimed |
| EP-1368348-B1 | NOVEL 2,5-DIAZABICYCLO(2.2.1)HEPTANE DERIVATIVES | NEUROSEARCH AS (DK) | 2005-01-19 | — | — | EP | claimed |
| US-20040181069-A1 | Novel 2,5-diazabicyclo[2.2.1]heptane derivatives | DANPET AB (SE) | 2004-09-16 | — | — | US | claimed |
| EP-1368348-A1 | NOVEL 2,5-DIAZABICYCLO(2.2.1)HEPTANE DERIVATIVES | NEUROSEARCH A/S (DK) | 2003-12-10 | — | — | EP | claimed |
| WO-2002070522-A1 | NOVEL 2,5-DIAZABICYCLO[2.2.1]HEPTANE DERIVATIVES | NEUROSEARCH A/S (DK) | 2002-09-12 | — | — | WO | claimed |
| US-7329754-B2 | 2,5-diazabicyclo[2.2.1]heptane derivatives | NEUROSEARCH A/S (DK) | 2008-02-12 | — | — | US | disclosed |
| EP-1368348-B1 | NOVEL 2,5-DIAZABICYCLO(2.2.1)HEPTANE DERIVATIVES | NEUROSEARCH AS (DK) | 2005-01-19 | — | — | EP | disclosed |
| US-20040181069-A1 | Novel 2,5-diazabicyclo[2.2.1]heptane derivatives | DANPET AB (SE) | 2004-09-16 | — | — | US | disclosed |
| EP-1368348-A1 | NOVEL 2,5-DIAZABICYCLO(2.2.1)HEPTANE DERIVATIVES | NEUROSEARCH A/S (DK) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002070522-A1 | NOVEL 2,5-DIAZABICYCLO[2.2.1]HEPTANE DERIVATIVES | NEUROSEARCH A/S (DK) | 2002-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040181069-A1 | Novel 2,5-diazabicyclo[2.2.1]heptane derivatives | CHRNA2, CHRNB2, CHRNA10 | KDM4E 3292/4885MEN1 3420/4885NPC1 1227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.