Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | IL6 | P05231 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.39 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28336820 | 0.85 | NFKB1 (0.45) | MEN1LMNATHRBBLMKMT2A | |
| SCHEMBL1125930 | 0.84 | NFKB1 (0.40) | MEN1LMNATHRBBLMKMT2A | |
| SCHEMBL29417728 | 0.83 | NFKB1 (0.57) | MEN1LMNATHRBBLMKMT2A | |
| SCHEMBL67207 | 0.83 | NFKB1 (0.57) | MEN1LMNATHRBBLMKMT2A | |
| SCHEMBL28066003 | 0.83 | KIF11 (0.41) | NFKB1PSMB8HSD11B1ALDH1A1HPGD | |
| SCHEMBL26262578 | 0.81 | ERN1 (0.42) | NFKB1PSMB8HSD11B1ALDH1A1HPGD | |
| SCHEMBL27016125 | 0.81 | HSD11B1 (0.41) | LMNATDP1HSD11B1ALDH1A1TSHR | |
| SCHEMBL7083651 | 0.80 | HSD11B1 (0.42) | NFKB1HSD11B1ALDH1A1HPGDTNF | |
| SCHEMBL31175932 | 0.80 | KMT2A (0.71) | MEN1LMNATHRBBLMKMT2A | |
| SCHEMBL249552 | 0.80 | KMT2A (0.71) | MEN1LMNATHRBBLMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7345079-B2 | Treatment of disorder related to low cyclic GMP levels | YUNG SHIN PHARMACEUTICALS INDUSTRIAL CO., LTD (TW) | 2008-03-18 | — | — | US | disclosed |
| EP-1425015-A4 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-12-15 | — | — | EP | disclosed |
| EP-1425015-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-09 | — | — | EP | disclosed |
| US-20030220385-A1 | Treatment of disorder related to low cyclic GMP levels | YUNG SHIN PHARMACEUTICALS INDUSTRIAL CO., LT.D (TW) | 2003-11-27 | — | — | US | disclosed |
| WO-2003015715-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-02-27 | — | — | WO | disclosed |
| US-4753936-A | CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1988-06-28 | — | — | US | disclosed |
| EP-0234196-A1 | Substituted 1,4-dihydropyridine-3-carboxylic acid piperazides, process for their preparation and their use in medicaments | BAYER AG (DE) | 1987-09-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220385-A1 | Treatment of disorder related to low cyclic GMP levels | PDE7A, PDE2A, PDE4A | MEN1 2548/4885LMNA 1031/4885THRB 830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.