Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4849151 | 0.84 | MEN1 (0.54) | MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL11871949 | 0.83 | MEN1 (0.56) | MAPTALDH1A1KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL11864597 | 0.81 | MEN1 (0.55) | MAPTALDH1A1KDM4ELMNARAB9A | |
| SCHEMBL1482081 | 0.81 | HDAC3 (0.56) | ALDH1A1KDM4EDRD4LMNAHDAC3 | |
| SCHEMBL4848385 | 0.80 | CYP2A13 (0.59) | MAPTALDH1A1KDM4ELMNANPC1 | |
| SCHEMBL14032449 | 0.76 | ACHE (0.60) | MAPTALDH1A1ACHEDRD4RAB9A | |
| SCHEMBL27883990 | 0.76 | MPO (0.72) | MAPTALDH1A1ACHEKDM4ESIGMAR1 | |
| SCHEMBL13136021 | 0.75 | MAOA (0.42) | MAPTALDH1A1KDM4ELMNAHDAC3 | |
| SCHEMBL8550581 | 0.74 | MAPT (0.57) | MAPTALDH1A1ACHEKDM4ELMNA | |
| SCHEMBL8551446 | 0.74 | ALDH1A1 (0.64) | MAPTALDH1A1KDM4ESIGMAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20060052600-A1 | Amino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-03-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |