⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20778 | 0.92 | — | — | |
| SCHEMBL28111215 | 0.74 | LOXL2 (0.37) | — | |
| SCHEMBL28783039 | 0.73 | — | — | |
| SCHEMBL7822554 | 0.73 | — | — | |
| SCHEMBL3076052 | 0.72 | USP2 (0.31) | — | |
| SCHEMBL16935766 | 0.72 | KDM4E (0.37) | — | |
| SCHEMBL2378465 | 0.71 | — | — | |
| SCHEMBL526546 | 0.71 | — | — | |
| SCHEMBL5937200 | 0.71 | — | — | |
| SCHEMBL8521841 | 0.70 | PTGS2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342038-B2 | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment or prevention of diseases characterized by abnormal cell proliferation | PRESIDENT AND FELLOW OF HARVARD COLLEGE (US) | 2008-03-11 | — | — | US | disclosed |
| US-20040242563-A1 | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment or prevention of diseases characterized by abnormal cell proliferation | CHILDREN'S MEDICAL CENTER CORPORATION | 2004-12-02 | — | — | US | disclosed |
| US-6800658-B2 | A POTENT AND SAFE INHIBITORS OF MAMMALIAN CELL PROLIFERATION FOR TREATING OR PREVENTING CANCER, BLOOD VESSEL PROLIFERATIVE DISORDERS, FIBROTIC DISORDERS AND ARTERIOSCLEROTIC CONDITIONS | CHILDREN'S MEDICAL CENTER CORPORATION | 2004-10-05 | — | — | US | disclosed |
| EP-1047411-B1 | SUBSTITUTED DIPHENYL INDANONE, INDANE AND INDOLE COMPOUNDS AND ANALOGUES THEREOF USEFUL FOR THE TREATMENT OR PREVENTION OF DISEASES CHARACTERIZED BY ABNORMAL CELL PROLIFERATION | HARVARD COLLEGE (US) | 2004-02-11 | — | — | EP | disclosed |
| US-20020198188-A1 | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation | CHILDREN'S MEDICAL CENTER CORPORATION | 2002-12-26 | — | — | US | disclosed |
| US-20020128256-A1 | Methods for the treatment or prevention of inflammatory diseases characterized by abnormal cell proliferation | BRUGNARA CARLO (US) | 2002-09-12 | — | — | US | disclosed |