Sugi Predict

Sugi Predict / Compounds / SCHEMBL4847672

SCHEMBL4847672

SCHEMBL4847672

O=C1Cc2cc(O)ccc2ON1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 4/20 0.40
▸ MAOB P27338 4/20 0.40
▸ PRKCI P41743 1/20 0.40
▸ TDP2 O95551 4/20 0.38
▸ PBRM1 Q86U86 1/20 0.38
▸ MAPT P10636 2/20 0.37
▸ ALDH1A1 P00352 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ CYP3A4 P08684 1/20 0.37
▸ BRD4 O60885 1/20 0.36
▸ CREBBP Q92793 1/20 0.36
▸ ESR1 P03372 1/20 0.35
▸ ESR2 Q92731 1/20 0.35
▸ PDE3B Q13370 1/20 0.35
▸ PDE3A Q14432 1/20 0.35
▸ MAPKAPK2 P49137 1/20 0.35
▸ DRD2 P14416 1/20 0.34
▸ DRD4 P21917 1/20 0.34
▸ HSD17B1 P14061 1/20 0.34
▸ PTGS2 P35354 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10926837 0.86 ESR2 (0.42) MAOAMAOBPRKCITDP2PBRM1
SCHEMBL3922665 0.82 AHR (0.51) TDP2MAPTPDE3BPDE3A
SCHEMBL542110 0.79 TDP2 (0.49) TDP2PBRM1MAPTBRD4
SCHEMBL182522 0.79 CASP1 (0.42) TDP2MAPTALDH1A1RAB9AMAPKAPK2
SCHEMBL531586 0.78 TDP2 (0.49) TDP2MAPTALDH1A1PTGS2
Phenol SCHEMBL5504361 0.77 MAOB (0.39) MAOAMAOBTDP2MAPTALDH1A1
SCHEMBL6937 0.75 MAOA (0.48) MAOAMAOBTDP2
SCHEMBL29408741 0.75 MAOA (0.48) MAOAMAOBTDP2
SCHEMBL8623559 0.75 GAA (0.50) MAOAMAOBTDP2MAPTALDH1A1
SCHEMBL182798 0.73 TDP2 (0.54) TDP2MAPTALDH1A1RAB9ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7354915-B2 6-amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH (US) 2008-04-08 — — US disclosed
US-20070225281-A1 6-Amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH (US) 2007-09-27 — — US disclosed
US-7247625-B2 6-amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH (US) 2007-07-24 — — US disclosed
US-20050085470-A1 6-Amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators WYETH 2005-04-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085470-A1 6-Amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators PGR, FSHR, GPR6 MAOA 3129/4885MAOB 2225/4885PRKCI 4507/4885
US-20070225281-A1 6-Amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators PGR, FSHR, GPR6 MAOA 3129/4885MAOB 2225/4885PRKCI 4507/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.