Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RELA | Q04206 | 8/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ESRRG | P62508 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4853514 | 0.89 | NR1H4 (0.47) | KDRBCHEACHE | |
| SCHEMBL4856242 | 0.89 | BCHE (0.45) | RELABCHEACHESYKTNFRSF1A | |
| SCHEMBL4853736 | 0.89 | BCHE (0.52) | BCHEACHETNFRSF1A | |
| SCHEMBL4856637 | 0.89 | LMNA (0.45) | RELAKDRBCHEACHESYK | |
| SCHEMBL4846169 | 0.88 | BCHE (0.42) | KDRBCHEACHETNFRSF1APTPN1 | |
| SCHEMBL4852888 | 0.87 | HCRTR2 (0.42) | RELAKDRBCHEACHESYK | |
| SCHEMBL4847755 | 0.86 | TNFRSF1A (0.46) | RELATNFRSF1APTPN1 | |
| SCHEMBL4847320 | 0.86 | SNCA (0.44) | KDRBCHEACHESYKTNFRSF1A | |
| SCHEMBL4846042 | 0.85 | MAPT (0.50) | KDRBCHEACHE | |
| SCHEMBL4846060 | 0.85 | MAPT (0.50) | KDRBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | claimed |
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |