SCHEMBL484937

SCHEMBL484937

COc1cc(Cl)[c]c(Cl)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.53
CYP1A1 P04798 6/20 0.40
CYP1B1 Q16678 6/20 0.40
CYP3A4 P08684 3/20 0.39
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38
CA12 O43570 1/20 0.38
CA7 P43166 1/20 0.38
CA9 Q16790 1/20 0.38
CA14 Q9ULX7 1/20 0.38
CYP1A2 P05177 3/20 0.36
CYP2E1 P05181 2/20 0.36
CYP2C8 P10632 2/20 0.36
CYP2D6 P10635 2/20 0.36
CYP2A6 P11509 2/20 0.36
CYP2C9 P11712 2/20 0.36
CYP4B1 P13584 2/20 0.36
CYP2B6 P20813 2/20 0.36
CYP3A5 P20815 2/20 0.36
CYP2A7 P20853 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11359739 0.87 ALDH1A1 (0.46) ALDH1A1CYP1A1CYP1B1CYP3A4CA1
SCHEMBL17514699 0.85 CYP1A1 (0.50) ALDH1A1CYP1A1CYP1B1CYP3A4CYP1A2
SCHEMBL744029 0.85 ALDH1A1 (0.43) ALDH1A1CYP1A1CYP1B1CYP3A4CA1
SCHEMBL2347097 0.84 ALDH1A1 (0.42) ALDH1A1CYP1A1CYP1B1CYP3A4CA1
SCHEMBL455232 0.80 ALDH1A1 (0.39) ALDH1A1CYP1A1CYP1B1CYP3A4
SCHEMBL8306743 0.77 NPC1 (0.53) ALDH1A1CA1CA2CA12CA7
SCHEMBL17514831 0.73 CYP1A1 (0.42) ALDH1A1CYP1A1CYP1B1CYP3A4CYP1A2
SCHEMBL1859774 0.73 LTA4H (0.55) ALDH1A1CA1CA2CA12CA7
SCHEMBL1637019 0.72 NQO1 (0.46) ALDH1A1CYP3A4
1,3,5-Trimethoxybenzene SCHEMBL28493 0.71 ALDH1A1 (1.00) ALDH1A1CYP1A1CYP1B1CYP3A4CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 416 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100144674-A1 PYRIDAZINE DERIVATIVES SYNGENTA CROP PROTECTION, INC. (US) 2010-06-10 US claimed
US-20100113457-A1 NOVEL PYRIDAZINE DERIVATIVES SYNGENTA CROP PROTECTION, INC. (US) 2010-05-06 US claimed
US-20100113464-A1 NOVEL PYRIDAZINE DERIVATIVES SYNGENTA CROP PROTECTION, INC. (US) 2010-05-06 US claimed
US-20100022526-A1 PYRIDAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES SYNGENTA CROP PROTECTION, INC. (US) 2010-01-28 US claimed
EP-2121628-A1 PYRIDAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES Syngenta Participations AG (CH) 2009-11-25 EP claimed
EP-2121629-A1 NOVEL PYRIDAZINE DERIVATIVES Syngeta Participations AG (CH) 2009-11-25 EP claimed
EP-2077997-A1 PYRIDAZINE DERIVATIVES Syngeta Participations AG (CH) 2009-07-15 EP claimed
EP-2041113-A1 NOVEL PYRIDAZINE DERIVATIVES Syngeta Participations AG (CH) 2009-04-01 EP claimed
US-7435837-B2 Dihydrobenzofuranyl alkanamine derivatives and methods for using same WYETH (US) 2008-10-14 US claimed
WO-2008089934-A1 PYRIDAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES SYNGENTA PARTICIPATIONS AG (CH) 2008-07-31 WO claimed
US-6436961-B1 SUBSTANCE P RECEPTOR ANTAGONIST; 2-PHENYL-3-BENZYLAMINOPIPERIDINES PFIZER INC 2002-08-20 US claimed
EP-1224187-A2 CERTAIN ALKYLENE DIAMINE-SUBSTITUTED HETEROCYCLES NEUROGEN CORPORATION (US) 2002-07-24 EP claimed
WO-2002020485-A1 SPIROHETEROCYCLIC NITRILES USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2002-03-14 WO claimed
WO-2001023389-A2 CERTAIN ALKYLENE DIAMINE-SUBSTITUTED HETEROCYCLES NEUROGEN CORPORATION (US) 2001-04-05 WO claimed
US-4692529-A Method for synthesizing a magenta coupler by selectively etherifying 4-hydroxy-5-pyrazolone KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1987-09-08 US claimed
US-4514490-A COLORFASTNESS; COUPLER WITH METHYLENEDIOAY BENZENE GROUP FUJI PHOTO FILM CO., LTD. (JP) 1985-04-30 US claimed
US-4336325-A CONTAING A MAGENTA COLOR-FORMING COUPLER WHICH PREVENTS YELLOW STAIN FUJI PHOTO FILM CO., LTD. (JP) 1982-06-22 US claimed
US-4268592-A PYRAZOLONE MAGENTA COUPLER CIBA-GEIGY AG (CH) 1981-05-19 US claimed
EP-0007991-A1 Substituted 2-phenylamino-imidazolines-(2), their acid addition salts, medicaments containing them and processes for their preparation C.H. BOEHRINGER SOHN (DE) 1980-02-20 EP claimed
US-4163670-A PYRAZOLONE COUPLERS FUJI PHOTO FILM CO., LTD. (JP) 1979-08-07 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100113457-A1 NOVEL PYRIDAZINE DERIVATIVES C3AR1, C5, C1S ALDH1A1 1767/4885CYP1A1 58/4885CYP1B1 81/4885
US-20100022526-A1 PYRIDAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES CYP4Z1, CYP1A2, CYP1A1 ALDH1A1 481/4885CYP1A1 3/4885CYP1B1 7/4885
US-20100113464-A1 NOVEL PYRIDAZINE DERIVATIVES C3AR1, CBR3, C5 ALDH1A1 1380/4885CYP1A1 48/4885CYP1B1 65/4885
US-20100144674-A1 PYRIDAZINE DERIVATIVES C3AR1, C1S, CBR3 ALDH1A1 1874/4885CYP1A1 103/4885CYP1B1 228/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.