Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | CBLB | Q13191 | 2/20 | 0.36 |
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5127168 | 0.74 | PDE3B (0.39) | PARP10PARP11NOTUMAKR1C3AKR1C2 | |
| SCHEMBL5112467 | 0.72 | NOTUM (0.37) | PARP10PARP11NOTUMAKR1C3AKR1C2 | |
| SCHEMBL5126113 | 0.70 | PGR (0.40) | PARP10PARP11NOTUMAKR1C3AKR1C2 | |
| SCHEMBL4845544 | 0.70 | IL1RN (0.33) | MEN1POLBKMT2AMAPT | |
| SCHEMBL16193418 | 0.68 | HTR1A (0.48) | HTR1AHTR7PARP10PARP11NOTUM | |
| SCHEMBL6320969 | 0.66 | GSK3B (0.53) | HTR1AHTR7PARP10PARP11PARP1 | |
| SCHEMBL5124648 | 0.65 | PGR (0.47) | PARP10PARP11NOTUMAKR1C3AKR1C2 | |
| SCHEMBL16201911 | 0.65 | HTR1A (0.50) | HTR1AHTR7PARP10PARP11NOTUM | |
| SCHEMBL2744062 | 0.64 | HTR1A (0.47) | HTR1A | |
| SCHEMBL5118641 | 0.63 | PGR (0.44) | HTR1AHTR7PARP10PARP11NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435733-B2 | Mineralocorticoid receptor modulator compounds and methods, and pharmaceutical compositions containing these compounds | LIGAND PHARMACEUTICALS, INC. (US) | 2008-10-14 | — | — | US | claimed |
| US-20070185102-A1 | MINERALOCORTICOID RECEPTOR MODULATOR COMPOUNDS AND METHODS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | LIGAND PHARMACEUTICALS, INC. | 2007-08-09 | — | — | US | claimed |
| WO-2006023158-A2 | MINERALOCORTICOID RECEPTOR MODULATOR COMPOUNDS AND METHODS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | LIGAND PHARMACEUTICALS, INC. (US) | 2006-03-02 | — | — | WO | claimed |
| US-7435733-B2 | Mineralocorticoid receptor modulator compounds and methods, and pharmaceutical compositions containing these compounds | LIGAND PHARMACEUTICALS, INC. (US) | 2008-10-14 | — | — | US | disclosed |
| US-20070185102-A1 | MINERALOCORTICOID RECEPTOR MODULATOR COMPOUNDS AND METHODS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | LIGAND PHARMACEUTICALS, INC. | 2007-08-09 | — | — | US | disclosed |
| WO-2006023158-A2 | MINERALOCORTICOID RECEPTOR MODULATOR COMPOUNDS AND METHODS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | LIGAND PHARMACEUTICALS, INC. (US) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185102-A1 | MINERALOCORTICOID RECEPTOR MODULATOR COMPOUNDS AND METHODS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | NR3C2, MC2R, NR3C1 | HTR1A 563/4885HTR7 517/4885PARP10 3656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.