Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CES1 | P23141 | 5/20 | 0.42 |
| ▸ | CES2 | O00748 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 4/20 | 0.34 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1001349 | 1.00 | TSHR (0.43) | TSHRLMNACES1CES2THRB | |
| Hydrochloric Acid SCHEMBL4946144 | 0.96 | CES1 (0.41) | TSHRLMNACES1CES2THRB | |
| Hydrochloric Acid SCHEMBL1000866 | 0.96 | CES1 (0.41) | TSHRLMNACES1CES2THRB | |
| SCHEMBL21882 | 0.96 | — | — | |
| SCHEMBL11527395 | 0.92 | TSHR (0.43) | TSHRLMNACES1CES2THRB | |
| SCHEMBL747847 | 0.92 | TSHR (0.43) | TSHRLMNACES1CES2THRB | |
| Iodide SCHEMBL7869089 | 0.92 | TSHR (0.43) | TSHRLMNACES1CES2THRB | |
| SCHEMBL1406213 | 0.92 | CES2 (0.46) | TSHRLMNACES1CES2THRB | |
| SCHEMBL10591515 | 0.92 | TSHR (0.43) | TSHRLMNACES1CES2THRB | |
| SCHEMBL6689804 | 0.92 | TSHR (0.43) | TSHRLMNACES1CES2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1772501-A2 | Silicone-coated architectural glass | Industrial Control Development, Inc. (US) | 2007-04-11 | — | — | EP | claimed |
| US-9724363-B2 | Skin compositions and methods of use thereof | OLIVO LABORATORIES, LLC (US) | 2017-08-08 | — | — | US | disclosed |
| WO-2017117438-A1 | COMPOSITIONS AND METHODS FOR IMPROVING THE APPEARANCE OF THE SKIN | L'OREAL (FR) | 2017-07-06 | — | — | WO | disclosed |
| US-20170189317-A1 | COMPOSITIONS AND METHODS FOR IMPROVING THE APPEARANCE OF THE SKIN | L'OREAL (FR) | 2017-07-06 | — | — | US | disclosed |
| US-20160143840-A1 | SKIN COMPOSITIONS AND METHODS OF USE THEREOF | SHISEIDO COMPANY, LIMITED (JP) | 2016-05-26 | — | — | US | disclosed |
| EP-1772501-B1 | Silicone-coated architectural glass | IND CONTROL DEV INC (US) | 2015-08-12 | — | — | EP | disclosed |
| CN-103183830-B | Method for producing hydrophilic silicone polymer | PEGAVISION CORP | 2015-06-10 | — | — | CN | disclosed |
| US-20140004073-A1 | SKIN COMPOSITIONS AND METHODS OF USE THEREOF | SHISEIDO COMPANY, LIMITED (JP) | 2014-01-02 | — | — | US | disclosed |
| CN-103183830-A | Method for producing hydrophilic silicone polymer | PEGAVISION CORP | 2013-07-03 | — | — | CN | disclosed |
| US-7387841-B2 | Silicone-based cyanate-ester cross-linkable die attach adhesive | INTEL CORPORATION (US) | 2008-06-17 | — | — | US | disclosed |
| US-7211638-B2 | Silicone-based cyanate-ester cross-linkable die attach adhesive | INTEL CORPORATION (US) | 2007-05-01 | — | — | US | disclosed |
| EP-1772501-A2 | Silicone-coated architectural glass | Industrial Control Development, Inc. (US) | 2007-04-11 | — | — | EP | disclosed |
| US-20050159573-A1 | Silicone-based cyanate-ester cross-linkable die attach adhesive | JAYARAMAN SAIKUMAR (US) | 2005-07-21 | — | — | US | disclosed |
| US-20050014920-A1 | Silicone-based cyanate-ester cross-linkable die attach adhesive | INTEL CORPORATION | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170189317-A1 | COMPOSITIONS AND METHODS FOR IMPROVING THE APPEARANCE OF THE SKIN | CUTA, HPSE, VCL | TSHR 4567/4885LMNA 717/4885CES1 2968/4885 |
| US-20160143840-A1 | SKIN COMPOSITIONS AND METHODS OF USE THEREOF | CUTA, TYR, PLOD3 | TSHR 4655/4885LMNA 445/4885CES1 737/4885 |
| US-20140004073-A1 | SKIN COMPOSITIONS AND METHODS OF USE THEREOF | CUTA, TYR, PLOD3 | TSHR 4655/4885LMNA 445/4885CES1 737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.