Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 14/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | ARAF | P10398 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4861557 | 0.81 | BRAF (0.52) | NPC1RAB9AMAPTBRAFCSF1R | |
| SCHEMBL4861094 | 0.79 | KDR (0.42) | NPC1RAB9ABRAFRAF1ARAF | |
| SCHEMBL4788672 | 0.79 | LMNA (0.50) | NPC1RAB9ABRAFRAF1CSF1R | |
| SCHEMBL4789710 | 0.79 | BRAF (0.52) | BRAFCSF1RABL1SRCDDR1 | |
| SCHEMBL4789714 | 0.78 | BRAF (0.48) | MAPTBRAFRAF1CSF1RPIKFYVE | |
| SCHEMBL4861442 | 0.78 | BRAF (0.41) | BRAFRAF1CSF1RPIKFYVEABL1 | |
| SCHEMBL4788647 | 0.77 | LCK (0.46) | BRAFRAF1ARAFCSF1RABL1 | |
| SCHEMBL4788095 | 0.77 | BRAF (0.63) | BRAFRAF1ARAFCSF1RDDR1 | |
| SCHEMBL14027871 | 0.77 | JAK1 (0.42) | BRAF | |
| SCHEMBL4789788 | 0.77 | BMX (0.46) | NPC1RAB9ABRAFRAF1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |