Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tacrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 17/20 | 0.91 |
| ▸ | BCHE known ✓ | P06276 | 15/20 | 0.91 |
| ▸ | TSHR | P16473 | 3/20 | 0.91 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.91 |
| ▸ | THRB | P10828 | 2/20 | 0.91 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.91 |
| ▸ | LMNA | P02545 | 1/20 | 0.91 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.91 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.88 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.88 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.88 |
| ▸ | GRIN2A | Q12879 | 8/20 | 0.88 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.88 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.88 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.88 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.88 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.88 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.88 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.88 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tacrine SCHEMBL490750 | 0.95 | ACHE (1.00) | ACHEBCHETSHRHSD17B10THRB | |
| Tacrine SCHEMBL2330283 | 0.95 | ACHE (1.00) | ACHEBCHETSHRHSD17B10THRB | |
| Tacrine SCHEMBL1044163 | 0.95 | ACHE (1.00) | ACHEBCHETSHRHSD17B10THRB | |
| Tacrine SCHEMBL2330285 | 0.95 | ACHE (1.00) | ACHEBCHETSHRHSD17B10THRB | |
| Tacrine SCHEMBL7638777 | 0.95 | ACHE (1.00) | ACHEBCHETSHRHSD17B10THRB | |
| Tacrine SCHEMBL3270 | 0.95 | ACHE (1.00) | ACHEBCHETSHRHSD17B10THRB | |
| Tacrine SCHEMBL2236694 | 0.94 | THRB (1.00) | ACHEBCHETSHRHSD17B10THRB | |
| Tacrine SCHEMBL5580054 | 0.94 | THRB (1.00) | ACHEBCHETSHRHSD17B10THRB | |
| Tacrine SCHEMBL29681895 | 0.94 | ACHE (1.00) | ACHEBCHETSHRHSD17B10THRB | |
| Tacrine SCHEMBL2828 | 0.94 | ACHE (1.00) | ACHEBCHETSHRHSD17B10THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE40558-E1 | Therapeutic uses of di-aryl acid derivatives | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-10-28 | — | — | US | disclosed |
| US-6635655-B1 | Agonists or antagonists of peroxisome proliferator-activated receptors | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-10-21 | — | — | US | disclosed |