Sugi Predict

Sugi Predict / Compounds / SCHEMBL4850176

SCHEMBL4850176

SCHEMBL4850176

CCOC(=O)NC(Cc1ccc(F)cc1)C(=O)O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.54
▸ ITGB3 P05106 2/20 0.54
▸ ITGAV P06756 1/20 0.54
▸ ACE P12821 3/20 0.52
▸ MME P08473 3/20 0.52
▸ CPA1 P15085 2/20 0.52
▸ ACE2 Q9BYF1 2/20 0.52
▸ GPR34 Q9UPC5 2/20 0.50
▸ CTSS P25774 1/20 0.50
▸ CTSK P43235 1/20 0.50
▸ CA2 P00918 1/20 0.50
▸ NOS3 P29474 2/20 0.48
▸ NOS1 P29475 2/20 0.48
▸ NOS2 P35228 2/20 0.48
▸ TGM2 P21980 1/20 0.46
▸ EPHX2 P34913 1/20 0.46
▸ PPARG P37231 1/20 0.46
▸ FOLH1 Q04609 1/20 0.46
▸ CA12 O43570 1/20 0.45
▸ CA7 P43166 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18765748 1.00 ALDH1A1 (0.54) ALDH1A1ITGB3ITGAVACEMME
Hydrochloric Acid SCHEMBL27637902 0.99 ALDH1A1 (0.53) ALDH1A1ITGB3ITGAVACEMME
SCHEMBL18229003 0.89 MME (0.49) ALDH1A1ITGB3ITGAVACEMME
SCHEMBL32677087 0.89 NOS2 (0.61) ALDH1A1CTSSCTSKNOS3NOS1
SCHEMBL17064146 0.89 NOS2 (0.61) ALDH1A1CTSSCTSKNOS3NOS1
SCHEMBL17064145 0.89 NOS2 (0.61) ALDH1A1CTSSCTSKNOS3NOS1
SCHEMBL17070606 0.89 NOS2 (0.61) ALDH1A1CTSSCTSKNOS3NOS1
SCHEMBL9559423 0.87 FOLH1 (0.58) ITGB3ITGAVACEMMECPA1
SCHEMBL9559418 0.87 FOLH1 (0.58) ITGB3ITGAVACEMMECPA1
SCHEMBL996291 0.87 L3MBTL1 (0.58) ALDH1A1ITGB3ITGAVACEMME

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3365334-B1 BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS OTSUKA PHARMA CO LTD (JP) 2024-07-17 — — EP disclosed
US-11939321-B2 Benzolactam compounds as protein kinase inhibitors OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2024-03-26 — — US disclosed
US-20230019032-A1 BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2023-01-19 — — US disclosed
CN-114948963-A Protein kinase inhibitor benzolactam compounds 大冢制药株式会社 2022-08-30 — — CN disclosed
US-11339130-B1 Calpain modulators and therapeutic uses thereof BLADE THERAPEUTICS, INC. (US) 2022-05-24 — — US disclosed
CN-108617166-B Protein kinase inhibitor benzolactam compounds 大冢制药株式会社 2022-05-17 — — CN disclosed
US-11001575-B1 Benzolactam compounds as protein kinase inhibitors OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2021-05-11 — — US disclosed
US-10934261-B2 Calpain modulators and therapeutic uses thereof BLADE THERAPEUTICS, INC. (US) 2021-03-02 — — US disclosed
US-10894776-B2 — — 2021-01-19 — — US disclosed
US-20200123114-A1 CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF BLADE THERAPEUTICS, INC. (US) 2020-04-23 — — US disclosed
WO-2017068412-A1 BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2017-04-27 — — WO disclosed
US-7314879-B2 Melanocortin receptor agonists ELI LILLY AND COMPANY (US) 2008-01-01 — — US disclosed
US-7169777-B2 Melanocortin receptor agonists ELI LILLY AND COMPANY (US) 2007-01-30 — — US disclosed
EP-1469851-B1 MELANOCORTIN RECEPTOR AGONISTS LILLY CO ELI (US) 2006-10-11 — — EP disclosed
US-20050075344-A1 Melanocortin receptor agonists ELI LILLY AND COMPANY 2005-04-07 — — US disclosed
EP-1469851-A1 MELANOCORTIN RECEPTOR AGONISTS ELI LILLY AND COMPANY (US) 2004-10-27 — — EP disclosed
US-20040116699-A1 Melanocortin receptor agonists ELI LILLY AND COMPANY 2004-06-17 — — US disclosed
EP-1358163-A1 MELANOCORTIN RECEPTOR AGONISTS ELI LILLY AND COMPANY (US) 2003-11-05 — — EP disclosed
WO-2003061660-A1 MELANOCORTIN RECEPTOR AGONISTS ELI LILLY AND COMPANY (US) 2003-07-31 — — WO disclosed
WO-2002059095-A1 MELANOCORTIN RECEPTOR AGONISTS ELI LILLY AND COMPANY (US) 2002-08-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200123114-A1 CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF CAPNS1, CAPN9, CAPN1 ALDH1A1 4193/4885ITGB3 3215/4885ITGAV 3860/4885
US-11939321-B2 Benzolactam compounds as protein kinase inhibitors MAPK1, ALK, MAP3K1 ALDH1A1 1598/4885ITGB3 3395/4885ITGAV 4654/4885
US-10934261-B2 Calpain modulators and therapeutic uses thereof CAPNS1, CAPN9, CAPN1 ALDH1A1 4193/4885ITGB3 3215/4885ITGAV 3860/4885
US-20230019032-A1 BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS MAPK1, ALK, MAP3K1 ALDH1A1 1598/4885ITGB3 3395/4885ITGAV 4654/4885
US-10894776-B2 — CAPNS1, CAPN9, CAPN2 ALDH1A1 4421/4885ITGB3 2774/4885ITGAV 3127/4885
US-20050075344-A1 Melanocortin receptor agonists MC4R, MC1R, MC5R ALDH1A1 1354/4885ITGB3 2250/4885ITGAV 1942/4885
US-11339130-B1 Calpain modulators and therapeutic uses thereof CAPNS1, CAPN9, CAPN1 ALDH1A1 4193/4885ITGB3 3215/4885ITGAV 3860/4885
US-11001575-B1 Benzolactam compounds as protein kinase inhibitors MAPK1, ALK, MAP3K1 ALDH1A1 1601/4885ITGB3 3392/4885ITGAV 4660/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.