Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | RGS4 | P49798 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24120011 | 0.76 | MGLL (0.48) | CNR1MAPTALDH1A1KMT2ALMNA | |
| SCHEMBL4852057 | 0.72 | RGS4 (0.50) | RGS4MAPTALDH1A1KMT2ALMNA | |
| SCHEMBL8556230 | 0.70 | GRM5 (0.66) | MAPTALDH1A1KMT2ALMNAGRM5 | |
| SCHEMBL16047323 | 0.69 | GRM5 (0.47) | CNR1MAPTALDH1A1KMT2AGRM5 | |
| Hydrochloric Acid SCHEMBL27657032 | 0.69 | GRM5 (0.64) | MAPTALDH1A1KMT2ALMNAGRM5 | |
| SCHEMBL20574477 | 0.68 | RGS4 (0.50) | RGS4MAPTALDH1A1KMT2ALMNA | |
| SCHEMBL4845878 | 0.68 | RGS4 (0.46) | RGS4MAPTALDH1A1KMT2ALMNA | |
| SCHEMBL3470129 | 0.67 | RGS4 (0.53) | CNR1RGS4MAPTALDH1A1KMT2A | |
| SCHEMBL235080 | 0.67 | KDM4E (0.65) | ALDH1A1KDM4EDAOTSHRCA1 | |
| SCHEMBL19588475 | 0.67 | ADRA1B (0.47) | CNR1ALDH1A1KMT2AKDM1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378419-B2 | 9-amino-podophyllotoxin derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | LES LABORATOIRES SERVIER (FR) | 2008-05-27 | — | — | US | disclosed |
| EP-1664055-B9 | 9-AMINO-PODOPHYLLOTOXIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | SERVIER LAB (FR) | 2007-10-10 | — | — | EP | disclosed |
| EP-1664055-B1 | 9-AMINO-PODOPHYLLOTOXIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES | SERVIER LAB (FR) | 2006-12-13 | — | — | EP | disclosed |
| US-20060247246-A1 | 9-Amino-podophyllotoxin derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2006-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060247246-A1 | 9-Amino-podophyllotoxin derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | SIK2, PTK2B, PLK2 | CNR1 1904/4885RGS4 3547/4885MAPT 4639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.