SCHEMBL4851897

SCHEMBL4851897

c1ccc2c(c1)Cc1cc3cc4c(cc3cc1-2)Cc1ccccc1-4

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.57
KDM4E B2RXH2 3/20 0.57
NPC1 O15118 3/20 0.57
MAPT P10636 3/20 0.57
RAB9A P51151 3/20 0.57
ALDH1A1 P00352 3/20 0.57
HPGD P15428 2/20 0.57
LMNA P02545 1/20 0.57
CYP3A4 P08684 5/20 0.50
TSHR P16473 5/20 0.50
HSD17B10 Q99714 4/20 0.50
CYP2C9 P11712 4/20 0.50
TP53 P04637 3/20 0.50
CYP2D6 P10635 3/20 0.50
MAPK1 P28482 3/20 0.50
CYP2C19 P33261 3/20 0.50
MAOA P21397 2/20 0.50
MEN1 O00255 2/20 0.50
PKM P14618 2/20 0.50
KMT2A Q03164 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4851856 0.94 SMN1; SMN2 (0.52) SMN1; SMN2KDM4ENPC1MAPTRAB9A
Benzo[B]Fluorene SCHEMBL29367443 0.93 ALDH1A1 (0.55) SMN1; SMN2KDM4ENPC1MAPTRAB9A
Benzo[B]Fluorene SCHEMBL599104 0.93 ALDH1A1 (0.55) SMN1; SMN2KDM4ENPC1MAPTRAB9A
Benzo[B]Fluorene SCHEMBL30914260 0.93 ALDH1A1 (0.55) SMN1; SMN2KDM4ENPC1MAPTRAB9A
SCHEMBL5058433 0.87 SMN1; SMN2 (0.64) SMN1; SMN2KDM4ENPC1MAPTRAB9A
SCHEMBL18582934 0.87 SMN1; SMN2 (0.64) SMN1; SMN2KDM4ENPC1MAPTRAB9A
SCHEMBL5016641 0.87 SMN1; SMN2 (0.64) SMN1; SMN2KDM4ENPC1MAPTRAB9A
SCHEMBL30912172 0.87 SMN1; SMN2 (0.64) SMN1; SMN2KDM4ENPC1MAPTRAB9A
SCHEMBL3280539 0.85 SMN1; SMN2 (0.61) SMN1; SMN2KDM4ENPC1MAPTRAB9A
SCHEMBL29924230 0.85 SMN1; SMN2 (0.61) SMN1; SMN2KDM4ENPC1MAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7470290-B2 Hydroscopic polymer gels for easier cleaning THE CLOROX COMPANY (US) 2008-12-30 US disclosed
EP-1966842-A2 LIGHTING ELEMENTS, DEVICES AND METHODS Aldred, Matthew, P. (GB) 2008-09-10 EP disclosed
WO-2007064721-A2 LIGHTING ELEMENTS, DEVICES AND METHODS ALDRED MATTHEW P (GB) 2007-06-07 WO disclosed
US-7183010-B2 Organic light-emitting diode devices with improved operational stability EASTMAN KODAK CORPORATION (US) 2007-02-27 US disclosed
US-20050245428-A1 Hydroscopic polymer gels for easier cleaning RODRIGUES KLIN A 2005-11-03 US disclosed
US-20040076853-A1 Organic light-emitting diode devices with improved operational stability EASTMAN KODAK COMPANY 2004-04-22 US disclosed