Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TYMS | P04818 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL516630 | 0.93 | MEN1 (0.52) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL6756888 | 0.92 | MEN1 (0.59) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| Phenol SCHEMBL8103114 | 0.92 | MEN1 (0.59) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL29365596 | 0.92 | MEN1 (0.63) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL15691572 | 0.92 | MEN1 (0.63) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL900116 | 0.92 | MEN1 (0.63) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL45826 | 0.92 | MEN1 (0.63) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| Formaldehyde SCHEMBL972884 | 0.90 | MEN1 (0.57) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL28240230 | 0.90 | MEN1 (0.61) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL18184916 | 0.87 | MMP3 (0.56) | MEN1KMT2ALMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080300675-A1 | POLYMERIC STENTS AND OTHER SURGICAL ARTICLES | PENTCH MEDICAL DEVICED LTD., | 2008-12-04 | — | — | US | disclosed |
| US-7410498-B2 | Polymeric stents and other surgical articles | PENTECH MEDICAL DEVICES LTD. (IL) | 2008-08-12 | — | — | US | disclosed |
| EP-1416881-A4 | POLYMERIC STENTS AND OTHER SURGICAL ARTICLES | PENTECH MEDICAL DEVICES LTD (IL) | 2004-05-12 | — | — | EP | disclosed |
| EP-1416881-A2 | POLYMERIC STENTS AND OTHER SURGICAL ARTICLES | Pentech Medical Devices Ltd (IL) | 2004-05-12 | — | — | EP | disclosed |
| US-20030208259-A1 | Polymeric stents and other surgical articles | PENTECH MEDICAL DEVICES LTD. (IL) | 2003-11-06 | — | — | US | disclosed |
| WO-2002000092-A2 | POLYMERIC STENTS AND OTHER SURGICAL ARTICLES | PENTECH MEDICAL DEVICES LTD. (IL) | 2002-01-03 | — | — | WO | disclosed |
| EP-0704065-B1 | OCULAR LENS COMPOSITION AND METHOD OF FORMATION | RASOR ASS INC (US) | 2000-05-03 | — | — | EP | disclosed |
| US-5986001-A | THERMOFORMED GAS PERMEABLE LENSE WITH INTERPENETRATING NETWORK | RASOR ASSOCIATES, INC. (US) | 1999-11-16 | — | — | US | disclosed |
| US-5789483-A | GAS PERMEABLE | RASOR ASSOCIATES, INC. (US) | 1998-08-04 | — | — | US | disclosed |
| US-5723541-A | BLOCK POLYMER BLEND FOR LENSES OF SILICONES OR FLUOROPOLYMERS WITH POLYCARBONATES, POLYSULFONES AND POLYSTYRENE WITH ACRYLATES, METHACRYLATES, PYRROLIDONE, AMIDE AND NITRILES | RASOR ASSOCIATES, INC. (US) | 1998-03-03 | — | — | US | disclosed |
| EP-0704065-A1 | OCULAR LENS COMPOSITION AND METHOD OF FORMATION | RASOR ASSOCIATES, INC. (US) | 1996-04-03 | — | — | EP | disclosed |
| WO-1994029756-A2 | OCULAR LENS COMPOSITION AND METHOD OF FORMATION | RASOR ASSOCIATES, INC. (US) | 1994-12-22 | — | — | WO | disclosed |