Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.33 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.32 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4854724 | 0.86 | MAPT (0.35) | BACE1MAPTGAAKMT2ASQOR | |
| SCHEMBL4853603 | 0.79 | TDP1 (0.38) | CYP1A2MAPTKMT2ATDP1IKBKB | |
| SCHEMBL4858979 | 0.68 | SCN2A (0.53) | — | |
| SCHEMBL4861188 | 0.68 | PIK3CA (0.33) | MAPTGAAKMT2ATDP1SMN1; SMN2 | |
| SCHEMBL4853527 | 0.67 | KMO (0.33) | CYP1A2MAPTGAAKMT2ATDP1 | |
| SCHEMBL28635180 | 0.66 | KMT2A (0.50) | CYP1A2MAPTKMT2ASQORIKBKB | |
| SCHEMBL4857517 | 0.66 | CBFB (0.34) | — | |
| SCHEMBL7365766 | 0.65 | APLNR (0.45) | MAPTGAAKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL4782507 | 0.64 | RAB9A (0.47) | CYP1A2MAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL16052311 | 0.64 | DHODH (0.41) | MAPTGAAKMT2ATDP1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470713-B2 | Imidazole based kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470713-B2 | Imidazole based kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470713-B2 | Imidazole based kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-30 | — | — | US | disclosed |
| WO-2005082885-A1 | IMIDAZOLE BASED KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-09-09 | — | — | WO | disclosed |
| US-20050187218-A1 | Imidazole based kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187218-A1 | Imidazole based kinase inhibitors | MAP3K19, MAP3K1, ABL1 | BACE1 4053/4885CYP1A2 2308/4885MAPT 2267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.