Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | GALR2 | O43603 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4853755 | 0.78 | CRHR1 (0.43) | MAPK1LMNAMAPTCRHR1KDM5A | |
| SCHEMBL19700421 | 0.61 | CRHR1 (0.42) | MAPK1LMNAMAPTCRHR1NPSR1 | |
| SCHEMBL1334869 | 0.60 | RAPGEF4 (0.74) | ALDH1A1NPC1RAB9AMAPK1LMNA | |
| SCHEMBL30320262 | 0.60 | RAPGEF4 (0.74) | ALDH1A1NPC1RAB9AMAPK1LMNA | |
| SCHEMBL15603543 | 0.60 | KDM5A (0.40) | KDM5AKDM4CKDM5B | |
| SCHEMBL9879894 | 0.60 | GAA (0.57) | ALDH1A1NPC1RAB9AMAPK1LMNA | |
| SCHEMBL4855605 | 0.60 | MAPT (0.41) | ALDH1A1NPC1RAB9AMAPK1LMNA | |
| SCHEMBL11564238 | 0.59 | RAPGEF4 (0.61) | ALDH1A1NPC1RAB9AMAPK1LMNA | |
| SCHEMBL8348988 | 0.57 | RAPGEF4 (0.52) | ALDH1A1NPC1RAB9AMAPK1LMNA | |
| SCHEMBL22814342 | 0.57 | RAPGEF4 (0.63) | ALDH1A1NPC1RAB9AMAPK10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414059-B2 | Pyrazolyl and imidazolyl pyrimidines as CRF antagonists | ROCHE PALO ALTO LLC (US) | 2008-08-19 | — | — | US | disclosed |
| US-7414059-B2 | Pyrazolyl and imidazolyl pyrimidines as CRF antagonists | ROCHE PALO ALTO LLC (US) | 2008-08-19 | — | — | US | disclosed |
| US-7414059-B2 | Pyrazolyl and imidazolyl pyrimidines as CRF antagonists | ROCHE PALO ALTO LLC (US) | 2008-08-19 | — | — | US | disclosed |
| US-20050113382-A1 | Spiro tetrahydroquinazolines and dihydrocyclopentapyrimidines as CRF antagonists | ROCHE PALO ALTO LLC | 2005-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113382-A1 | Spiro tetrahydroquinazolines and dihydrocyclopentapyrimidines as CRF antagonists | AVPR2, CRHR1, CRHR2 | ALDH1A1 1058/4885NPC1 890/4885RAB9A 758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.