Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5807905 | 0.80 | PTGS2 (0.65) | PTGS2ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL29953592 | 0.79 | PTGS2 (0.59) | PTGS2ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL4848372 | 0.79 | PTGS2 (0.63) | PTGS2ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL719535 | 0.79 | PTGS2 (0.63) | PTGS2ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL14435489 | 0.78 | PTGS2 (0.58) | PTGS2ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL23928527 | 0.78 | PTGS2 (0.80) | PTGS2ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL7652166 | 0.78 | PTGS2 (0.66) | PTGS2ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL3447906 | 0.77 | PTGS2 (1.00) | PTGS2ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL28561271 | 0.75 | ALDH1A1 (0.53) | PTGS2ALDH1A1KMT2ASMN1; SMN2POLB | |
| SCHEMBL16830535 | 0.75 | PTGS2 (0.58) | PTGS2ALDH1A1KMT2ASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368578-B2 | Five-membered heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-06 | — | — | US | disclosed |
| US-20060135578-A1 | Five-membered heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-06-22 | — | — | US | disclosed |
| EP-1541564-A1 | FIVE-MEMBERED HETEROCYCLIC COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2005-06-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135578-A1 | Five-membered heterocyclic compounds | GPR119, OR10J3, CYP11B1 | PTGS2 2206/4885ALDH1A1 821/4885KMT2A 1792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.