Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.53 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.53 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28632640 | 0.88 | LMNA (0.54) | ALDH1A1HSD17B10MAPTPTGS1CXCR1 | |
| SCHEMBL1888517 | 0.85 | ALDH1A1 (0.56) | ALDH1A1HSD17B10CYP1A2NAPRTSMN1; SMN2 | |
| SCHEMBL8774039 | 0.85 | MAPT (0.51) | ALDH1A1HSD17B10MAPTPTGS1CXCR1 | |
| SCHEMBL104492 | 0.84 | ALDH1A1 (0.59) | ALDH1A1HSD17B10CYP1A2NAPRTSMN1; SMN2 | |
| SCHEMBL729868 | 0.83 | PTGS1 (0.56) | ALDH1A1HSD17B10CYP1A2MAPTPTGS1 | |
| SCHEMBL11359244 | 0.82 | ALDH1A1 (0.56) | ALDH1A1HSD17B10CYP1A2NAPRTMAPT | |
| SCHEMBL23046942 | 0.81 | ALDH1A1 (0.56) | ALDH1A1HSD17B10CYP1A2NAPRTSMN1; SMN2 | |
| SCHEMBL4362389 | 0.81 | ALDH1A1 (0.59) | ALDH1A1HSD17B10CYP1A2NAPRTSMN1; SMN2 | |
| SCHEMBL602096 | 0.80 | PTGS2 (0.69) | ALDH1A1HSD17B10CYP1A2MAPTPTGS1 | |
| SCHEMBL10754027 | 0.80 | POLB (0.54) | ALDH1A1HSD17B10CYP1A2NAPRTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
| US-4692447-A | HYPOTENSIVE, VASODILATOR, ANTITHROMBOTIC, ANTIAGGREGANT, CYTOPROTECTIVE | BOEHRINGER BIOCHEMIA ROBIN, S.P.A. (IT) | 1987-09-08 | — | — | US | disclosed |
| EP-0169443-A2 | Tricyclic dihydropyridazinones and pharmaceutical compositions contaning them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1986-01-29 | — | — | EP | disclosed |
| US-4250252-A | A DEVELOPMENT-INHIBITOR-RELEASING COMPOUND COMPRISING A 5-(SULFOAMIDO-1-INDANONE-2-YL)THIO-TETRAZOLE | AGFA-GEVAERT, A.G. (DE) | 1981-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | ALDH1A1 3257/4885HSD17B10 2543/4885CYP1A2 3589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.