SCHEMBL4855247

SCHEMBL4855247

NS(=O)(=O)C1c2ccccc2Oc2ccccc21

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 2/20 0.50
MAOA P21397 1/20 0.48
MAOB P27338 1/20 0.48
CYP2C9 P11712 1/20 0.46
HDAC3 O15379 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
HDAC9 Q9UKV0 1/20 0.43
HDAC5 Q9UQL6 1/20 0.43
FFAR4 Q5NUL3 1/20 0.42
MEN1 O00255 4/20 0.40
KMT2A Q03164 4/20 0.40
USP2 O75604 1/20 0.40
CA2 P00918 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6996495 0.83 MAOA (0.52) ATMMAOAMAOBCYP2C9HDAC3
SCHEMBL29945051 0.79 MAOA (0.54) ATMMAOAMAOBCYP2C9HDAC3
SCHEMBL9226919 0.79 MAOA (0.48) ATMMAOAMAOBCYP2C9HDAC3
SCHEMBL2098387 0.79 MAOA (0.54) ATMMAOAMAOBCYP2C9HDAC3
SCHEMBL31474870 0.76 MAOA (0.45) ATMMAOAMAOBCYP2C9HDAC3
SCHEMBL10387973 0.76 CA2 (0.34) ATMCYP2C9CA2
SCHEMBL10425774 0.76 CA1 (0.50) MAOAHDAC3HDAC4HDAC7HDAC8
SCHEMBL28968619 0.71 FFAR4 (0.40) ATMMAOAMAOBCYP2C9HDAC3
SCHEMBL88261 0.70 MAOA (0.58) ATMMAOAMAOBCYP2C9HDAC3
SCHEMBL3236129 0.70 MAOA (0.58) ATMMAOAMAOBCYP2C9HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7367994-B2 Composition for dyeing keratin fibers, comprising a sulfonamidoxanthene direct dye, and dyeing process using the same L'ORéAL S.A. (FR) 2008-05-06 US disclosed
US-20060230545-A1 Composition for dyeing keratin fibers, comprising a sulfonamidoxanthene direct dye, and dyeing process using the same L'OREAL S.A. (FR) 2006-10-19 US disclosed
WO-2005038496-A2 DIGITAL DYES BASED ON ELECTROCHEMICAL REDOX REACTIONS HEWLETT-PACKARD DEVELOPMENT COMPANY L.P. (US) 2005-04-28 WO disclosed
US-20050084204-A1 Digital dyes based on electrochemical redox reactions HEWLETT-PACKARD DEVELOPMENT COMPANY L.P. 2005-04-21 US disclosed
US-5399709-A N-substituted triarylmethane sulfonamides and method of preparation POLAROID CORPORATION (US) 1995-03-21 US disclosed
US-5399709-A N-substituted triarylmethane sulfonamides and method of preparation POLAROID CORPORATION (US) 1995-03-21 US disclosed
US-5332654-A Sulfonamide triarylmethane dye POLAROID CORPORATION (US) 1994-07-26 US disclosed
US-5332654-A Sulfonamide triarylmethane dye POLAROID CORPORATION (US) 1994-07-26 US disclosed
US-5258279-A IMAGE RECORDING MEDIA POLAROID CORPORATION (US) 1993-11-02 US disclosed
US-5258279-A IMAGE RECORDING MEDIA POLAROID CORPORATION (US) 1993-11-02 US disclosed
EP-0516163-A1 Reversible redox-controlled imaging methods POLAROID CORPORATION (US) 1992-12-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060230545-A1 Composition for dyeing keratin fibers, comprising a sulfonamidoxanthene direct dye, and dyeing process using the same KRT18, S100A4, DSG1 ATM 2809/4885MAOA 1669/4885MAOB 2214/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.