⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4858067 | 0.79 | GAA (0.32) | — | |
| SCHEMBL4114063 | 0.74 | PDK1 (0.36) | — | |
| Trifluoroacetic Acid SCHEMBL4855744 | 0.74 | DPP8 (0.39) | — | |
| Trifluoroacetic Acid SCHEMBL28847772 | 0.70 | DPP8 (0.36) | — | |
| SCHEMBL22765546 | 0.68 | SAT1 (0.32) | — | |
| SCHEMBL12424344 | 0.68 | HSD11B1 (0.40) | — | |
| SCHEMBL15794940 | 0.68 | — | — | |
| SCHEMBL12424261 | 0.67 | DRD3 (0.40) | — | |
| SCHEMBL2224685 | 0.67 | PRKACA (0.33) | — | |
| SCHEMBL15655416 | 0.67 | SCN9A (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234020-A1 | Thrombopoietin mimetics | SMITHKLINE BEECHAM CORP. | 2005-10-20 | — | — | US | claimed |
| EP-1556059-A1 | THROMBOPOIETIN MIMETICS | Smithkline Beecham (US) | 2005-07-27 | — | — | EP | claimed |
| WO-2003103686-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-12-18 | — | — | WO | claimed |
| US-7414040-B2 | Thrombopoietin mimetics | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-19 | — | — | US | disclosed |
| US-20050234020-A1 | Thrombopoietin mimetics | SMITHKLINE BEECHAM CORP. | 2005-10-20 | — | — | US | disclosed |
| EP-1556059-A1 | THROMBOPOIETIN MIMETICS | Smithkline Beecham (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2003103686-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-12-18 | — | — | WO | disclosed |