Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL28847772 | 0.82 | DPP8 (0.36) | DPP8DPP7 | |
| Trifluoroacetic Acid SCHEMBL22505630 | 0.78 | PKM (0.38) | DPP8DPP7DPP4PKMEPHX2 | |
| Trifluoroacetic Acid SCHEMBL4858060 | 0.77 | GAA (0.36) | DPP8DPP7SLC1A2DPP4ALDH1A1 | |
| SCHEMBL4855748 | 0.74 | — | — | |
| Trifluoroacetic Acid SCHEMBL16050159 | 0.71 | PDK1 (0.39) | DPP8DPP4EPHX2ALDH1A1LMNA | |
| Trifluoroacetic Acid SCHEMBL4114059 | 0.71 | PDK1 (0.39) | DPP8DPP4EPHX2ALDH1A1LMNA | |
| SCHEMBL12424344 | 0.71 | HSD11B1 (0.40) | PKMEPHX2 | |
| SCHEMBL12424261 | 0.70 | DRD3 (0.40) | PKMALDH1A1MAPT | |
| Trifluoroacetic Acid SCHEMBL3862637 | 0.70 | PDK1 (0.42) | EPHX2ALDH1A1LMNAMAPT | |
| SCHEMBL25117890 | 0.68 | ATM (0.46) | EPHX2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234020-A1 | Thrombopoietin mimetics | SMITHKLINE BEECHAM CORP. | 2005-10-20 | — | — | US | claimed |
| EP-1556059-A1 | THROMBOPOIETIN MIMETICS | Smithkline Beecham (US) | 2005-07-27 | — | — | EP | claimed |
| WO-2003103686-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-12-18 | — | — | WO | claimed |
| US-7414040-B2 | Thrombopoietin mimetics | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-19 | — | — | US | disclosed |
| US-20050234020-A1 | Thrombopoietin mimetics | SMITHKLINE BEECHAM CORP. | 2005-10-20 | — | — | US | disclosed |
| EP-1556059-A1 | THROMBOPOIETIN MIMETICS | Smithkline Beecham (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2003103686-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234020-A1 | Thrombopoietin mimetics | MPL, THPO, TEK | DPP8 2828/4885DPP7 3340/4885SLC1A2 4516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.