Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ECE1 | P42892 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL589964 | 0.87 | EPHX2 (0.40) | NOS2EPHX2EPHX1PRMT1 | |
| SCHEMBL15224160 | 0.83 | EPHX1 (0.63) | EPHX2EPHX1MMP1MMP2 | |
| SCHEMBL23173031 | 0.80 | EPHX1 (0.52) | NOS2EPHX2EPHX1PRMT1ALDH1A1 | |
| SCHEMBL6867263 | 0.79 | EPHX1 (0.73) | EPHX2EPHX1 | |
| SCHEMBL19173064 | 0.79 | EPHX1 (0.43) | NOS2EPHX2EPHX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7259183 | 0.79 | EPHX2 (0.58) | NOS2EPHX2EPHX1PRMT1ECE1 | |
| SCHEMBL24860396 | 0.78 | ALDH1A1 (0.54) | EPHX2ALDH1A1MMP1MMP2MMP3 | |
| SCHEMBL320068 | 0.77 | — | — | |
| SCHEMBL28293734 | 0.77 | MMP1 (0.48) | EPHX2EPHX1FAAHALDH1A1SMN1; SMN2 | |
| SCHEMBL12502963 | 0.76 | EPHX2 (0.38) | NOS2EPHX2EPHX1FAAHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008525522-A | — | — | 2008-07-17 | — | — | JP | claimed |
| EP-1844022-A1 | QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF | Hanmi Pharm. Co., Ltd. (KR) | 2007-10-17 | — | — | EP | claimed |
| WO-2006071017-A1 | QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF | HANMI PHARM. CO., LTD. (KR) | 2006-07-06 | — | — | WO | claimed |