Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4854586 | 0.86 | ROCK2 (0.52) | GSK3BROCK2ROCK1NPC1RAB9A | |
| SCHEMBL5233935 | 0.84 | ROCK2 (0.40) | GSK3BROCK2RAB9ALIPGALDH1A1 | |
| SCHEMBL5232508 | 0.77 | MAPK8 (0.55) | GSK3BROCK2MAPK8MKNK1MKNK2 | |
| SCHEMBL14348317 | 0.76 | GSK3B (0.45) | GSK3BROCK2ROCK1NPC1RAB9A | |
| SCHEMBL5233639 | 0.75 | GSK3B (0.52) | GSK3BROCK2ROCK1MAPK8MKNK1 | |
| SCHEMBL5236116 | 0.75 | GSK3B (0.52) | GSK3BROCK2ROCK1MAPK8MKNK2 | |
| SCHEMBL4848283 | 0.74 | GSK3B (0.51) | GSK3BROCK2ROCK1MAPK8MKNK2 | |
| SCHEMBL13986943 | 0.74 | ALDH1A1 (0.53) | GSK3BROCK2NPC1RAB9AMKNK1 | |
| SCHEMBL14348304 | 0.74 | ALDH1A1 (0.53) | GSK3BROCK2NPC1RAB9AMKNK1 | |
| SCHEMBL13986936 | 0.73 | MAPK8 (0.51) | GSK3BROCK2MAPK8MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |