Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Guanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PNP | P00491 | 4/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanine SCHEMBL4301039 | 0.84 | KDM4E (0.44) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL5259 | 0.83 | ALDH1A1 (0.61) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL4658042 | 0.83 | ALDH1A1 (0.61) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL9512016 | 0.81 | ALDH1A1 (0.59) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL21611717 | 0.81 | ALDH1A1 (0.59) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL4063556 | 0.81 | ALDH1A1 (0.59) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL28240965 | 0.81 | ALDH1A1 (0.59) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL2895087 | 0.81 | ALDH1A1 (0.59) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL865492 | 0.81 | ALDH1A1 (0.59) | KDM4EALDH1A1LMNAGLAPMP22 | |
| Guanine SCHEMBL28373862 | 0.81 | ALDH1A1 (0.59) | KDM4EALDH1A1LMNAGLAPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7439351-B2 | 2′ or 3′ -deoxy and 2′, 3′-dideoxy-β-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti-viral agents | THE UAB RESEARCH FOUNDATION (US) | 2008-10-21 | — | — | US | disclosed |
| US-20050101776-A1 | 2' or 3' -deoxy and 2' , 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti-viral agents | GOSSELIN GILLES (FR) | 2005-05-12 | — | — | US | disclosed |
| US-20020120130-A1 | 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents | GOSSELIN GILLES (FR) | 2002-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101776-A1 | 2' or 3' -deoxy and 2' , 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti-viral agents | DUT, DCTD, DERA | KDM4E 2857/4885ALDH1A1 448/4885LMNA 1101/4885 |
| US-20020120130-A1 | 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents | DUT, DCTD, TYMP | KDM4E 2409/4885ALDH1A1 498/4885LMNA 952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.